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Galectins Structure and Function — A Synopsis

  • Chapter
Mammalian Carbohydrate Recognition Systems

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 33))

Abstract

Galectins are defined as proteins with at least one carbohydrate recognition domain (CRD) that has (1) certain conserved sequence elements, and (2) affinity for β–galactoside-containing glycoconjugates and saccharides (Barondes et al. 1994a). Almost all galectins discovered so far are small (14–36kDa), soluble proteins with one or two CRDs. There are now ten known mammalian galectins (Fig. 1) and many in other species, including birds, amphibians, fish, worms, sponges, and a fungus (Barondes et al. 1994b; Kasai and Hirabayashi 1996; Cooper et al. 1997; Leffler 1997; Muller 1997). The sequences in the EST databanks suggest the existence of at least another eight in mammals as well as putative galectins in insects, plants, and viruses (Cooper and Barondes 1999).

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  1. Department of Microbiology, Immunology and Glycobiology (MIG), Institute of Laboratory Medicine, Lund University, Sölvegatan 23, SE 22362, Lund, Sweden

    Hakon Leffler

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  1. The Wellcome Trust Building, Dept. of Biochemistry, University of Dundee, DD1 4HN, Dundee, Scotland

    Paul R. Crocker

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Leffler, H. (2001). Galectins Structure and Function — A Synopsis. In: Crocker, P.R. (eds) Mammalian Carbohydrate Recognition Systems. Results and Problems in Cell Differentiation, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-46410-5_4

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