Abstract
In previous work a novel information-theoretic approach was introduced for calculating the activation map for fMRI analysis [Tsai et al, 1999]. In that work the use of mutual information as a measure of activation resulted in a nonparametric calculation of the activation map. Nonparametric approaches are attractive as the implicit assumptions are milder than the strong assumptions of popular approaches based on the general linear model popularized by Friston et al [1994]. Here we show that, in addition to the intuitive information-theoretic appeal, such an application of mutual information is equivalent to a hypothesis test when the underlying densities are unknown. Furthermore we incorporate local spatial priors using the well-known Ising model thereby dropping the implicit assumption that neighboring voxel time-series are independent. As a consequence of the hypothesis testing equivalence, calculation of the activation map with local spatial priors can be formulated as mincut/maxflow graph-cutting problem. Such problems can be solved in polynomial time by the Ford and Fulkerson method. Empirical results are presented on three fMRI datasets measuring motor, auditory, and visual cortex activation. Comparisons are made illustrating the differences between the proposed technique and one based on the general linear model.
J. Kim, J. Fisher, A. Tsai, and A. Willsky supported in part by AFOSR grant F49620-98-1-0349, subcontract GC123919NGD from BU under the AFOSR Multidisciplinary Research Program, and ONR grant N00014-00-1-0089. C. Wible was supported in part under NIMH grants MH40799 and MH52807. W. Wells was supported in part by the Whitaker foundation and by NIH through grant 1P41RR13218.
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Kim, J., Fisher, J.W., Tsai, A., Wible, C., Willsky, A.S., Wells, W.M. (2000). Incorporating Spatial Priors into an Information Theoretic Approach for fMRI Data Analysis. In: Delp, S.L., DiGoia, A.M., Jaramaz, B. (eds) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2000. MICCAI 2000. Lecture Notes in Computer Science, vol 1935. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-40899-4_7
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DOI: https://doi.org/10.1007/978-3-540-40899-4_7
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