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Toxic and Beneficial Potential of Silver Nanoparticles: The Two Sides of the Same Coin

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Cellular and Molecular Toxicology of Nanoparticles

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1048))

Abstract

Nanotechnology has allowed great changes in chemical, biological and physical properties of metals when compared to their bulk counterparts. Within this context, silver nanoparticles (AgNPs) play a major role due to their unique properties, being widely used in daily products such as fabrics, washing machines, water filters, food and medicine. However, AgNPs can enter cells inducing a “Trojan-horse” type mechanism which potentially leads to cellular autophagy, apoptosis or necrosis. On the other hand, this cytotoxicity mechanism can be optimized to develop drug nanocarriers and anticancer therapies. The increasing use of these NPs entails their release into the environment, damaging ecosystems balance and representing a threat to human health. In this context, the possible deleterious effects that these NPs may represent for the biotic and abiotic ecosystems components represent an obstacle that must be overcome in order to guarantee the safety use of their unique properties.

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Authors and Affiliations

  1. Department of Chemistry, FFCLRP-USP, University of São Paulo – USP, Ribeirão Preto, SP, Brazil

    Lilian Rodrigues Rosa Souza

  2. Department of Biology, ICB-UFMG, Federal University of Minas Gerais – UFMG, Belo Horizonte, MG, Brazil

    Veronica Santana da Silva

  3. Department of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto; USP, Ribeirão Preto, São Paulo, Brazil

    Leonardo Pereira Franchi

  4. Department of Genetics, Faculty of Medicine of Ribeirão Preto; USP, Ribeirão Preto, São Paulo, Brazil

    Tiago Alves Jorge de Souza

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  1. Lilian Rodrigues Rosa Souza
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  2. Veronica Santana da Silva
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  3. Leonardo Pereira Franchi
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  4. Tiago Alves Jorge de Souza
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Correspondence to Tiago Alves Jorge de Souza .

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Editors and Affiliations

  1. Zoology Department, College of Sciences, King Saud University, Riyadh, Saudi Arabia

    Quaiser Saquib

  2. Department of Botany and Microbiology, College of Sciences, King Saud University, Riyadh, Saudi Arabia

    Mohammad Faisal

  3. Zoology Department, College of Sciences, King Saud University, Riyadh, Saudi Arabia

    Abdulaziz A. Al-Khedhairy

  4. Department of Botany and Microbiology, College of Sciences, King Saud University, Riyadh, Saudi Arabia

    Abdulrahman A. Alatar

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Souza, L.R.R., da Silva, V.S., Franchi, L.P., de Souza, T.A.J. (2018). Toxic and Beneficial Potential of Silver Nanoparticles: The Two Sides of the Same Coin. In: Saquib, Q., Faisal, M., Al-Khedhairy, A., Alatar, A. (eds) Cellular and Molecular Toxicology of Nanoparticles. Advances in Experimental Medicine and Biology, vol 1048. Springer, Cham. https://doi.org/10.1007/978-3-319-72041-8_15

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