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Mitochondria and Endoplasmic Reticulum: The Lethal Interorganelle Cross-Talk

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Abstract

The fundamental contribution of the mitochondria and ER to the decision made on the cell’s fate has been increasingly recognized. This progress has illuminated the need for the mechanisms these organelles use to initiate and to propagate apoptotic signals. The toolbox of the mitochondria and ER is evolutionary conserved, overlapping and complementary. Furthermore, mitochondria are often closely associated with the ER providing the conditions for a local and privileged communication between the two organelles. The present review is concerned with the spatially and temporally coordinated utilization of Bcl-2 family proteins and Ca2+ by the mitochondria and ER to control the membrane permeabilization in the mitochondria and to regulate Ca2+ distribution and the activity of apoptotic proteins in the ER. The apoptotic means of the mitochondria and ER will eventually come together to control the dismantling of the cell by the caspases and other enzymes.

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Authors and Affiliations

  1. Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107

    Ludivine Walter & György Hajnóczky

  2. Department of Pathology, Anatomy and Cell Biology, Suite 253 JAH, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107

    György Hajnóczky

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  1. Ludivine Walter
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  2. György Hajnóczky
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Correspondence to György Hajnóczky.

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Walter, L., Hajnóczky, G. Mitochondria and Endoplasmic Reticulum: The Lethal Interorganelle Cross-Talk. J Bioenerg Biomembr 37, 191–206 (2005). https://doi.org/10.1007/s10863-005-6600-x

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  • DOI: https://doi.org/10.1007/s10863-005-6600-x

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