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From Dose to Response: In Vivo Nanoparticle Processing and Potential Toxicity

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Modelling the Toxicity of Nanoparticles

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 947))

Abstract

Adverse human health impacts due to occupational and environmental exposures to manufactured nanoparticles are of concern and pose a potential threat to the continued industrial use and integration of nanomaterials into commercial products. This chapter addresses the inter-relationship between dose and response and will elucidate on how the dynamic chemical and physical transformation and breakdown of the nanoparticles at the cellular and subcellular levels can lead to the in vivo formation of new reaction products. The dose-response relationship is complicated by the continuous physicochemical transformations in the nanoparticles induced by the dynamics of the biological system, where dose, bio-processing, and response are related in a non-linear manner. Nanoscale alterations are monitored using high-resolution imaging combined with in situ elemental analysis and emphasis is placed on the importance of the precision of characterization. The result is an in-depth understanding of the starting particles, the particle transformation in a biological environment, and the physiological response.

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Authors and Affiliations

  1. University of Kentucky, Lexington, KY, USA

    Uschi M. Graham, Gary Jacobs, Robert A. Yokel & Burtron H. Davis

  2. CDC/NIOSH DART, Cincinnati, OH, USA

    Uschi M. Graham, Alan K. Dozier & M. Eileen Birch

  3. University of Louisville, Louisville, KY, USA

    Michael T. Tseng

  4. University of Rochester, Rochester, NY, USA

    Günter Oberdörster, Alison Elder & Lisa DeLouise

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  1. Uschi M. Graham
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Correspondence to Uschi M. Graham .

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Editors and Affiliations

  1. Institute of Occupational Medicine, Edinburgh, United Kingdom

    Lang Tran

  2. Institute of Catalysis & Petrochemistry, CSIC, Madrid, Spain

    Miguel A. Bañares

  3. Universitat Rovira i Virgili, Departament d’Enginyeria Informatica i Matematiques, Tarragona, Spain

    Robert Rallo

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Graham, U.M. et al. (2017). From Dose to Response: In Vivo Nanoparticle Processing and Potential Toxicity. In: Tran, L., Bañares, M., Rallo, R. (eds) Modelling the Toxicity of Nanoparticles. Advances in Experimental Medicine and Biology, vol 947. Springer, Cham. https://doi.org/10.1007/978-3-319-47754-1_4

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