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Bioreactor Technology for Sustainable Production of Plant Cell-Derived Products

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Bioprocessing of Plant In Vitro Systems

Part of the book series: Reference Series in Phytochemistry ((RSP))

Abstract

The successful cultivation of plant cell and tissue cultures for the production of valuable chemical components requires the selection of an appropriate bioreactor. Selection criteria are determined based on a number of factors that are intrinsic to particular plant cell or tissue cultures and are influenced by the process objectives. Due to the specific properties of plant cell and tissue cultures, bioreactor systems may differ significantly from those used for microorganism or animal cell cultures. Furthermore, the differences from one plant culture to another can be immense; it is obvious that the optimal bioreactor system for a plant suspension cell culture is different to one for a plant tissue culture in many ways.

General considerations are presented, and based on these key points, selection criteria are used to establish a “bioreactor chooser” tool. The particular details of the most relevant bioreactor types for plant cell and tissue cultures are listed and described.

To produce valuable products, the process also needs to be scaled up to an economically justifiable size, which is usually done either by scaling up the size of the bioreactor itself or by bioreactor parallelization. Therefore, the most significant influencing factors are also discussed.

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Abbreviations

2G12:

Human monoclonal antibody 2G12

DAF-Fc:

Decay-accelerating factor-fragment crystallizable region

DPP4-Fc:

Dipeptidyl peptidase-4 fragment crystallizable region

FDA:

Federal Drug Administration

GAD65:

Glutamate decarboxylase 65

GMP:

Good manufacturing practice

HA:

Hemagglutinin

HCPS:

Hantavirus cardiopulmonary syndrome

hG-CSF:

Human granulocyte colony-stimulating factor

hGM-CSF:

Human granulocyte-macrophage colony-stimulating factor

ICAM-1-IgA2:

Intercellular adhesion molecule 1-Immunoglobulin A2

ICH:

International Conference on Harmonization

IL-12:

Interleukin 12

MERS:

Middle East respiratory syndrome

OUR:

Oxygen uptake rate

QbD:

Quality by design

RITA:

Récipient à immersion temporaire automatique

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  1. LSFM School of Life Sciences and Facility Management, ICBT Institute of Chemistry and Biotechnology, ZHAW Zurich University of Applied Sciences, Campus Grüental, 8820, Wädenswil, Switzerland

    Sören Werner, Rüdiger W. Maschke, Dieter Eibl & Regine Eibl

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  1. Sören Werner
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  2. Rüdiger W. Maschke
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  3. Dieter Eibl
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  4. Regine Eibl
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Correspondence to Sören Werner .

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Editors and Affiliations

  1. University of Food Technologies , Plovdiv, Bulgaria

    Atanas Pavlov

  2. Bioprocess Engineering, TU Dresden, Institute of Food Technology and Bioprocess Engineering, TU Dresden, Dresden, Germany

    Thomas Bley

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© 2017 Springer International Publishing AG

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Werner, S., Maschke, R.W., Eibl, D., Eibl, R. (2017). Bioreactor Technology for Sustainable Production of Plant Cell-Derived Products. In: Pavlov, A., Bley, T. (eds) Bioprocessing of Plant In Vitro Systems. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-319-32004-5_6-1

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  • DOI: https://doi.org/10.1007/978-3-319-32004-5_6-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-32004-5

  • Online ISBN: 978-3-319-32004-5

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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