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Application of Bioactive Compounds from Scutellaria in Neurologic Disorders

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The Benefits of Natural Products for Neurodegenerative Diseases

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 12))

Abstract

Inflammation of the brain is one of the most highly researched yet mysterious areas in modern day neurology. The process of inflammation is a normal mechanism of wound healing that can result from acute injuries such as traumas or can be caused by genetic/environmental factors. After the initial insult, the immune system defenses, specifically microglial cells, are activated in order to combat the infection or injury. However, prolonged or chronic inflammation is often deleterious due mainly to accumulation of free reactive oxygen species (ROS) and other pro-inflammatory cytokines in the brain FADDIN EN.CITE. Plant-derived natural compounds have the potential to ameliorate the causes and symptoms of neuroinflammation, due to their various anti-oxidant and anti-inflammatory activities, without completely muting the immune defenses. Scutellaria is a perennial plant in the mint family that has been used to treat diseases in Asia and Eastern Europe throughout history. This chapter reviews the active components of various Scutellaria species and their mechanisms of action to prevent chronic neurologic disorders involving neuroinflammation and neurodegeneration.

An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-3-319-28383-8_24

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Acknowledgment

We acknowledge research support from the USDA-NIFA (CSREES Award No. 2011-38821-30928 and Fund for Medical Research and Education (FMRE), WSU).

Compliance with Ethics Requirements The authors declare that they have no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Wayne State University School of Medicine, and Karmanos Cancer Institute, Lande Research Building, #460, 540 E. Canfield St., Detroit, MI, 48201, USA

    Farhan Hussain & Prahlad Parajuli Ph.D.

  2. Departments of Neurosurgery and Oncology, Wayne State University School of Medicine, and Karmanos Cancer Institute, 930 Harper POB, 4100 John R. St, Detroit, MI, 48201, USA

    Sandeep Mittal

  3. Graduate Program in Biotechnology, Agricultural Research Station, Fort Valley State University, Fort Valley, GA, USA

    Nirmal Joshee

Authors
  1. Farhan Hussain
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  2. Sandeep Mittal
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  3. Nirmal Joshee
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  4. Prahlad Parajuli Ph.D.
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Corresponding author

Correspondence to Prahlad Parajuli Ph.D. .

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Editors and Affiliations

  1. Food Science and Nutrition College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat, Oman

    M. Mohamed Essa

  2. National Institutes of Health, National Institute on Alcohol Abuse, Rockville, Maryland, USA

    Mohammed Akbar

  3. Australian School of Advanced Medicine, Macquarie University, Sydney, New South Wales, Australia

    Gilles Guillemin

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Hussain, F., Mittal, S., Joshee, N., Parajuli, P. (2016). Application of Bioactive Compounds from Scutellaria in Neurologic Disorders. In: Essa, M., Akbar, M., Guillemin, G. (eds) The Benefits of Natural Products for Neurodegenerative Diseases. Advances in Neurobiology, vol 12. Springer, Cham. https://doi.org/10.1007/978-3-319-28383-8_5

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