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MicroRNAs in Osteosarcomagenesis

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Current Advances in Osteosarcoma

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 804))

Abstract

The etiology of osteosarcoma (OS) remains enigmatic. Particular clinical and molecular patterns, observed with high frequency in OS, suggest that it results from some yet-to-be-discovered central driver. How else can biology generate such an aggressive, metastatic, genetically and chromosomally unstable malignancy with virtually no apparent precursor neoplasms that are partway along a disease path toward OS? With this conundrum as a backdrop, the discovery of every new native molecule with power to impact a cell’s biology is usually quickly followed by a search to see if this type of molecule contains the key to unlock OS biology.

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Author information

Authors and Affiliations

  1. Department of Orthopaedics and Center for Children’s Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA

    Lisa A. Kafchinski & Kevin B. Jones

Authors
  1. Lisa A. Kafchinski
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  2. Kevin B. Jones
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Corresponding author

Correspondence to Kevin B. Jones .

Editor information

Editors and Affiliations

  1. Division of Pediatrics, Department of Cancer Biology, The Mary V. and John A. Reilly Distinguished Chair, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Eugenie S. Kleinerman, M.D.

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© 2014 Springer International Publishing Switzerland

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Kafchinski, L.A., Jones, K.B. (2014). MicroRNAs in Osteosarcomagenesis. In: Kleinerman, M.D., E. (eds) Current Advances in Osteosarcoma. Advances in Experimental Medicine and Biology, vol 804. Springer, Cham. https://doi.org/10.1007/978-3-319-04843-7_6

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