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The functioning neuronal transporter for dopamine: kinetic mechanisms and effects of amphetamines, cocaine and methylphenidate

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Progress in Drug Research

Part of the book series: Progress in Drug Research ((PDR,volume 59))

Summary

The dopamine transporter (DAT) is a transmembrane spanning protein that catalyzes the transport of dopamine across the neuronal membrane to concentrate the neurotransmitter inside the cell. Although the uptake of dopamine has been studied since the 1960s, more recent advances in knowledge of the protein itself and in making kinetically resolved measurements of its action have led to more insights into its mechanism and pharmacology. The literature of the kinetics of transporters and kinetic measurements of DAT activity is reviewed to provide an overview of the multisubstrate mechanism of DAT activity, its pharmacology with regard to amphetamine, cocaine and methylphenidate, and correlations of DAT activity with some behavioral outputs.

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  1. Department of Chemistry, School of Molecular Biosciences, and Programs in Pharmacology/Toxicology and Neuroscience, Washington State University, Pullman, WA, 99164-4630, USA

    James O. Schenk

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  1. Steinweg 28, Ettingen, CH-4107, Switzerland

    Ernst Jucker

  2. Basel, Switzerland

    Ernst Jucker

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Schenk, J.O. (2002). The functioning neuronal transporter for dopamine: kinetic mechanisms and effects of amphetamines, cocaine and methylphenidate. In: Jucker, E. (eds) Progress in Drug Research. Progress in Drug Research, vol 59. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8171-5_4

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  • DOI: https://doi.org/10.1007/978-3-0348-8171-5_4

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9464-7

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