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Serotonin, dopamine and norepinephrine transporters in the central nervous system and their inhibitors

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Progress in Drug Research

Part of the book series: Progress in Drug Research ((PDR,volume 54))

Summary

An overview is presented on progress made in the research on neuronal transporters of serotonin, dopamine and norepinephrine in the central nervous system.

Tools developed by molecular biology, such as expression of cloned transporters, their mutants and chimera in non-neuronal cells offered the opportunity to study the putative domains for binding of substrates and uptake inhibitors and discover factors in the regulation of the transporter function. The study of the distribution of monoamine transporters in human brain became possible by the development of selective radiolabelled transport inhibitors.

The relationships between the chemical structure of the uptake inhibitors and the affinity for the monoamine transporters is reported, and the (potential) therapeutic applications of the compounds are discussed.

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Authors and Affiliations

  1. Dept. of Psychopharmacology, Faculty of Pharmacy, Utrecht University, Sorbonnelaan 16, Utrecht, CA, NL-3584, The Netherlands

    Berend Olivier

  2. PsychoGenics Inc., 4 Skyline Drive, Hawthorne, NY, 10532, USA

    Willem Soudijn & Ineke van Wijngaarden

  3. Dept. of Psychiatry, Yale University School of Medicine, 34 Park St., New Haven, CT, 06508, USA

    Willem Soudijn & Ineke van Wijngaarden

  4. Leiden/Amsterdam Center for Drug Research, P.O. Box 9502, Leiden, RA, NL-2300, The Netherlands

    Willem Soudijn & Ineke van Wijngaarden

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  1. Berend Olivier
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  1. Steinweg 28, Ettingen, CH-4107, Switzerland

    Ernst Jucker

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Olivier, B., Soudijn, W., van Wijngaarden, I. (2000). Serotonin, dopamine and norepinephrine transporters in the central nervous system and their inhibitors. In: Jucker, E. (eds) Progress in Drug Research. Progress in Drug Research, vol 54. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8391-7_3

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