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Bone Morphogenetic Proteins in Inflammation

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Encyclopedia of Inflammatory Diseases

Synonyms

Atherosclerosis; BMP; Bone repair; ECM; Inflammation; Inflammatory bowel disease; Liver disease

Definition

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor β (TGFβ) superfamily and control multiple organogenetic processes, cell proliferation and differentiation, apoptosis, and patterning of multiple organs from all three developmental envelopes including the skeleton, kidney, heart, pancreas, and eye. BMPs also have a role in inflammatory disorders via their actions on the immune system and inflammation, specifically in systemic diseases, including chronic liver disease, inflammatory bowel disease, iron deficiency anemia, vascular disease, atherosclerosis, rheumatoid arthritis, and ankylosing spondylitis, and in patients with implanted BMP2- and BMP7-based bone devices (Vukicevic et al. 2014).

Biosynthesis and Release

BMPs are synthesized and folded as large dimeric proteins in the cytoplasm and cleaved by proteases during secretion. Among 17...

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Authors and Affiliations

  1. Department of Anatomy, Laboratory for Mineralized Tissues, Center for Translational and Clinical Research, University of Zagreb School of Medicine, Ĺ alata, Zagreb, Croatia

    Slobodan Vukicevic & Lovorka Grgurevic

Authors
  1. Slobodan Vukicevic
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  2. Lovorka Grgurevic
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Correspondence to Slobodan Vukicevic .

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Editors and Affiliations

  1. Inst of Clinical Pharmacology Haus 74/75, JW Goethe University Frankfurt Fraunhofer IME, Frankfurt, Germany

    Michael Parnham

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Vukicevic, S., Grgurevic, L. (2014). Bone Morphogenetic Proteins in Inflammation. In: Parnham, M. (eds) Encyclopedia of Inflammatory Diseases. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-0620-6_212-1

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  • DOI: https://doi.org/10.1007/978-3-0348-0620-6_212-1

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