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BDNF Gene as a Precision Skill of Obesity Management

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Recent Advances in NGF and Related Molecules

Part of the book series: Advances in Experimental Medicine and Biology ((CNNCSN,volume 1331))

Abstract

The scarcity of the results obtained for the treatment of obesity leads us to consider new strategies, contemplating all the factors involved in the development of the disease. One of the key molecules for controlling body weight and energy homeostasis is the brain-derived neurotrophic factor (BDNF). This work summarizes the mechanisms in which BDNF gene regulates this multifactorial disease. In addition, we discuss the role of other BDNF polymorphisms as genetic determinants of obesity. In this context, a total of 14 SNPs near or inside BDNF/BDNF-AS related to BMI were identified in various GWASs. Finally, we assess gene-diet interaction as a novel tool to prevent obesity and formulate solid and personalized nutritional management. Our research group has performed the first study on the association of BDNF-AS rs925946 polymorphism and calcium intake as potential modulators of the nutritional status. Although these results should be confirmed in future studies, they open the path for new prevention opportunities.

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Acknowledgments

MPI is supported by the TALENTO Program from the Regional Madrid Government (2018-T1/BIO-11262).

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Authors and Affiliations

  1. Nutrition and Clinical Trials Unit, GENYAL Platform, IMDEA-Food Institute, CEI UAM + CSIC, Madrid, Spain

    Helena Marcos-Pasero, Elena Aguilar-Aguilar & Viviana Loria-Kohen

  2. Translational Venomics Group, IMDEA-Food, CEI UAM+CSIC, Madrid, Spain

    Maria P. Ikonomopoulou

  3. Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia

    Maria P. Ikonomopoulou

  4. Department of Nutrition and Food Science, Faculty of Pharmacy, Complutense University of Madrid, Madrid, Spain

    Viviana Loria-Kohen

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  1. Helena Marcos-Pasero
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  2. Elena Aguilar-Aguilar
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  3. Maria P. Ikonomopoulou
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  4. Viviana Loria-Kohen
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Correspondence to Viviana Loria-Kohen .

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  1. University of Bologna, Ozzano dell’Emilia, Bologna, Italy

    Laura Calzà

  2. IRET Foundation, Ozzano dell’Emilia, Bologna, Italy

    Luigi Aloe

  3. University of Bologna, Ozzano dell’Emilia, Bologna, Italy

    Luciana Giardino

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Marcos-Pasero, H., Aguilar-Aguilar, E., Ikonomopoulou, M.P., Loria-Kohen, V. (2021). BDNF Gene as a Precision Skill of Obesity Management. In: Calzà, L., Aloe, L., Giardino, L. (eds) Recent Advances in NGF and Related Molecules. Advances in Experimental Medicine and Biology(), vol 1331. Springer, Cham. https://doi.org/10.1007/978-3-030-74046-7_15

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