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Rationale and Methods for Assessment of Pain-Depressed Behavior in Preclinical Assays of Pain and Analgesia

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Analgesia

Part of the book series: Methods in Molecular Biology ((MIMB,volume 617))

Abstract

Pain-depressed behavior can be defined as any behavior that decreases in rate, frequency, duration, or intensity in response to a putative pain state. Common examples include pain-related decreases in feeding, locomotion and expression of positively reinforced operant behavior. In humans, depression of behavior is often accompanied by a comorbid depression of mood. Measurements of pain-depressed behaviors are used to diagnose pain in both human and veterinary medicine, and restoration of pain-depressed behavior is often a priority of treatment. This article describes two strategies for integrating measures of pain-depressed behaviors into preclinical assays of pain and analgesia. Assays of pain-depressed behaviors may contribute both to improved translational efficiency in analgesic drug development and to new insights regarding the mechanisms and determinants of pain and analgesia.

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Author information

Authors and Affiliations

  1. Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA

    S. Stevens Negus

  2. Department of Pharmacology, University of New England College of Osteopathic Medicine, Biddeford, ME, USA

    Edward J. Bilsky

  3. School of Social and Behavioral Sciences, Marist College, Poughkeepsie, NY, USA

    Gail Pereira Do Carmo

  4. Department of Psychology, University of New England, Biddeford, ME, USA

    Glenn W. Stevenson

Authors
  1. S. Stevens Negus
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  2. Edward J. Bilsky
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  3. Gail Pereira Do Carmo
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  4. Glenn W. Stevenson
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Corresponding author

Correspondence to S. Stevens Negus .

Editor information

Editors and Affiliations

  1. Dept. Pathology, Monmouth Medical Center, Second Ave. 300, Long Branch, 07750, USA

    Arpad Szallasi

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Negus, S.S., Bilsky, E.J., Carmo, G.P.D., Stevenson, G.W. (2010). Rationale and Methods for Assessment of Pain-Depressed Behavior in Preclinical Assays of Pain and Analgesia. In: Szallasi, A. (eds) Analgesia. Methods in Molecular Biology, vol 617. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-323-7_7

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  • DOI: https://doi.org/10.1007/978-1-60327-323-7_7

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60327-322-0

  • Online ISBN: 978-1-60327-323-7

  • eBook Packages: Springer Protocols

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