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The Principles of Freeze-Drying

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Cryopreservation and Freeze-Drying Protocols

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1257))

Abstract

This chapter provides an up-to-date overview of freeze-drying (lyophilization) with particular relevance to stabilizing live cells or viruses for industrial applications as vaccines or seed culture. The chapter discusses the importance of formulation, cycle development, validation, and the need to satisfy pharmaceutical regulatory requirements necessary for the commercial exploitation of freeze-dried products.

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Authors and Affiliations

  1. Biopharma Technology Ltd, Biopharma House, Winnall Valley Road, Winchester, SO23 0LD, UK

    Isobel Cook & Kevin R. Ward Ph.D.

Authors
  1. Gerald D. J. Adams
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  2. Isobel Cook
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  3. Kevin R. Ward Ph.D.
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Corresponding author

Correspondence to Kevin R. Ward Ph.D. .

Editor information

Editors and Affiliations

  1. Institute of Multiphase Processes, Leibniz Universität Hannover, Hannover, Germany

    Willem F. Wolkers

  2. Unit for Reproductive Medicine, Clinic for Horses, University of Veterinary Medicine Hannover, Hannover, Germany

    Harriëtte Oldenhof

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Adams, G.D.J., Cook, I., Ward, K.R. (2015). The Principles of Freeze-Drying. In: Wolkers, W., Oldenhof, H. (eds) Cryopreservation and Freeze-Drying Protocols. Methods in Molecular Biology, vol 1257. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2193-5_4

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  • DOI: https://doi.org/10.1007/978-1-4939-2193-5_4

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-2192-8

  • Online ISBN: 978-1-4939-2193-5

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