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History of Lyophilization

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Lyophilized Biologics and Vaccines

Abstract

Lyophilization, also known as freeze-drying, is a process known from the ancient times for preserving material by dehydrating the sample, which includes first freezing the sample and then drying under a vacuum at very low temperatures. This chapter covers its origin, definition, and key historical events that led to the development of modern day freeze-drying, and its widespread applications ranging from basic food needs to biotechnology products. Special consideration is given to the history of lyophilization process, lyophilized vaccines, and biopharmaceuticals.

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Author information

Authors and Affiliations

  1. MS & T Hospira, Inc., 275 N. Field Drive Lake Forest, Lake Forest, IL, 60045, USA

    Dushyant Varshney Ph.D.

  2. Novartis Vaccines and Diagnostics, Holly Springs, NC, 27540, USA

    Dushyant Varshney Ph.D. & Manmohan Singh

Authors
  1. Dushyant Varshney Ph.D.
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  2. Manmohan Singh
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Correspondence to Dushyant Varshney Ph.D. .

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Editors and Affiliations

  1. Novartis Vaccines and Diagnostics, Holly Springs, North Carolina, USA

    Dushyant Varshney

  2. Novartis Vaccines and Diagnostics, Holly Springs, North Carolina, USA

    Manmohan Singh

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Varshney, D., Singh, M. (2015). History of Lyophilization. In: Varshney, D., Singh, M. (eds) Lyophilized Biologics and Vaccines. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2383-0_1

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