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Translating the Intervention Approach into an Appropriate Research Design: The Next-Generation Adaptive Designs for Effectiveness and Implementation Research

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Defining Prevention Science

Part of the book series: Advances in Prevention Science ((Adv. Prevention Science))

Abstract

New prevention approaches require innovative research designs to maximize our ability to obtain answers to research questions. This chapter provides an overview of new research designs that address both effectiveness and implementation research in prevention. It also includes a discussion of what we have called adaptive or hybrid designs that integrate the concepts of effectiveness and implementation into an ongoing trial. These adaptive designs have the flexibility to adapt to changes in research questions and yet maintain the rigor associated with randomized control trials. We illustrate these approaches with examples from recent studies and point the way toward the design of future trials for prevention.

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Acknowledgments

We thank all our research colleagues and California and Ohio participants on the CAL-OH project, the Center for Prevention Implementation Methodology (Ce-PIM), and the Implementation Methods Research Group (IMRG). For her work in leading the CAL-OH project we thank Dr. Patricia Chamberlain. For the CYDS, the authors would like to acknowledge Dr. J. David Hawkins, Principal Investigator of the CYDS and Founding Director of the Social Development Research Group, School of Social Work, University of Washington. We gratefully acknowledge our colleagues on the CSP prevention trial and colleagues and the 24 communities in the CYDS trial. We especially thank our funders: National Institute on Drug Abuse (NIDA) for funding Ce-PIM (P30DA027828) along with the Office of Behavioral and Social Science Research, NIDA finding of the CYDS project (R01DA025651, R01DA015183) with co-funding from the National Cancer Institute, the National Institute of Child Health and Human Development, the National Institute of Mental Health, the Center for Substance Abuse Prevention, and the National Institute on Alcohol Abuse and Alcoholism. We also acknowledge support from the National Institute of Mental Health for the Prevention Science and Methodology Group (R01MH040859), the CAL-OH project (R01MH076158), and the IMRG Center (P30MH074678). We additionally thank the National Institute of General Medical Sciences (NIGMS) and the National Institute of Minority Health and Health Disparities (NIMHD) for support under the University of Miami’s Center for Translational Science (UL1TR000460) and the National Institute of Allergy and Infectious Diseases (NIAID) Miami Center for AIDS Research (P30AI073961). The content of this chapter is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.

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Authors and Affiliations

  1. Department of Epidemiology and Public Health, Miller School of Medicine, University of Miami, Miami, FL, USA

    C. Hendricks Brown

  2. National Research Institute for Child and Family Studies, Boys Town, NE, USA

    W. Alex Mason

  3. Social Development Research Group, School of Social Work, University of Washington, Seattle, WA, USA

    Eric C. Brown

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  1. C. Hendricks Brown
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Correspondence to C. Hendricks Brown .

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  1. Ontario, Ohio, USA

    Zili Sloboda

  2. JBS International, Inc., Rockville, USA

    Hanno Petras

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Brown, C.H., Mason, W.A., Brown, E.C. (2014). Translating the Intervention Approach into an Appropriate Research Design: The Next-Generation Adaptive Designs for Effectiveness and Implementation Research. In: Sloboda, Z., Petras, H. (eds) Defining Prevention Science. Advances in Prevention Science. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7424-2_16

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