Summary
Mediational selection designs can increase the chance of finding an intervention to be statistically better than a control when compared to interventions applied to a selected subpopulation such as all children of divorce. Selection based on poor mediational variable scores creates a high expectation that many subjects will benefit because it matches a population to a given intervention strategy. It does not permit examination of the impact on other subjects nor the possibility of interventions that may be tuned to the specific needs of different subpopulations. A sequence of trials each built on the results of previous ones has the potential for extending the results obtained from a mediational selection design.
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Brown, C.H. Comparison of mediational selected strategies and sequential designs for preventive trials: Comments on a proposal by pillow et al.. Am J Commun Psychol 19, 837–846 (1991). https://doi.org/10.1007/BF00937884
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DOI: https://doi.org/10.1007/BF00937884