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Heparan Sulfate Glycosaminoglycans as Primary Cell Surface Receptors for Herpes Simplex Virus

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Heparin and Related Polysaccharides

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 313))

Abstract

The purposes of this communication are (i) to summarize the evidence that heparan sulfate moieties of proteoglycans serve as cell surface receptors for herpes simplex virus (HSV) and (ii) to describe the heparin-binding viral glycoproteins that mediate the binding of virus to cells. These topics are discussed in the context of the molecular interactions required for entry of HSV into cells and, also, the pathology of HSV infections.

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Authors and Affiliations

  1. Microbiology-Immunology Department, Northwestern University Medical School, Chicago, IL, 60611, USA

    Patricia G. Spear, Mei-Tsu Shieh, Betsy C. Herold, Darrell WuDunn & Thomas I. Koshy

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  1. Patricia G. Spear
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  2. Mei-Tsu Shieh
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  3. Betsy C. Herold
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  4. Darrell WuDunn
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  5. Thomas I. Koshy
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Editors and Affiliations

  1. Charing Cross and Westminster Medical School, London, UK

    David A. Lane

  2. The Swedish University of Agricultural Sciences, Uppsala, Sweden

    Ingemar Björk

  3. Uppsala University, Uppsala, Sweden

    Ulf Lindahl

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Spear, P.G., Shieh, MT., Herold, B.C., WuDunn, D., Koshy, T.I. (1992). Heparan Sulfate Glycosaminoglycans as Primary Cell Surface Receptors for Herpes Simplex Virus. In: Lane, D.A., Björk, I., Lindahl, U. (eds) Heparin and Related Polysaccharides. Advances in Experimental Medicine and Biology, vol 313. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2444-5_33

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  • DOI: https://doi.org/10.1007/978-1-4899-2444-5_33

  • Publisher Name: Springer, Boston, MA

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