Heparin and Related Polysaccharides

1. Front Matter

   Pages i-x

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2. Historical Aspects

   1. Heparin — an Introduction

      • Lennart Rodén, Sandya Ananth, Patrick Campbell, Tracy Curenton, Göran Ekborg, Stephen Manzella et al.

      Pages 1-20

3. Structural Properties of Heparin and Heparan Sulphate

   1. Chemical Synthesis and Hemisynthesis in the Field of Glycosaminoglycans

      • Maurice Petitou

      Pages 21-30

   2. Structural Analysis of Periodate-Oxidized Heparin

      • H. Edward Conrad, Yuchuan Guo

      Pages 31-36

   3. New Methodologies in Heparin Structure Analysis and the Generation of LMW Heparins

      • Robert J. Linhardt, Hui-ming Wang, Stephen A. Ampofo

      Pages 37-47

   4. Heparan Sulphate Proteoglycans: Molecular Organisation of Membrane-Associated Species and an Approach to Polysaccharide Sequence Analysis

      • John T. Gallagher, Jeremy E. Turnbull, Malcolm Lyon

      Pages 49-57

4. Heparin and Heparan Sulphate Proteoglycanscellular Aspects

   1. Regulation of the Gene that Encodes the Peptide Core of Heparin Proteoglycan and Other Proteoglycans that are Stored in the Secretory Granules of Hematopoietic Cells

      • Donald E. Humphries, Richard L. Stevens

      Pages 59-67

   2. Structural and Functional Diversity of the Heparan Sulfate Proteoglycans

      • Guido David

      Pages 69-78

   3. Syndecan — A Cell Surface Proteoglycan that Selectively Binds Extracellular Effector Molecules

      • Markku Jalkanen, Klaus Elenius, Markku Salmivirta

      Pages 79-85

   4. Heparan Sulfate Proteoglycans and Signalling in Cell Adhesion

      • Anne Woods, John R. Couchman

      Pages 87-96

5. Heparin and Heparan Sulphate Proteoglycansinteractions and Metabolism

   1. Animal Cell Mutants Defective in Heparan Sulfate Polymerization

      • Jeffrey D. Esko

      Pages 97-106

   2. Two Enzymes in One: N-Deacetylation and N-Sulfation in Heparin Biosynthesis are Catalyzed by the Same Protein

      • Lena Kjellén, Inger Pettersson, Erik Unger, Ulf Lindahl

      Pages 107-111

   3. Metabolism of Plasma Membrane-Associated Heparan Sulfate Proteoglycans

      • Masaki Yanagishita

      Pages 113-120

   4. Lysosomal Degradation of Heparin and Heparan Sulphate

      • Craig Freeman, John Hopwood

      Pages 121-134

   5. Heparin Binding Properties of the Carboxyl Terminal Domain of [A103,106,108] Antistasin 93–119

      • George D. Manley, Thomas J. Owen, John L. Krstenansky, Robert G. Brankamp, Alan D. Cardin

      Pages 135-140

   6. Heparin Protein Interactions

      • Fanyu Zhou, Teresia Höök, John A. Thompson, Magnus Höök

      Pages 141-153

6. Anticoagulant Proteins

   1. Role of Protein Conformational Changes, Surface Approximation and Protein Cofactors in Heparin-Accelerated Antithrombin-Proteinase Reactions

      • Steven T. Olson, Ingemar Björk

      Pages 155-165

   2. The Interaction of Glycosaminoglycans with Heparin Cofactor II: Structure and Activity of a High-Affinity Dermatan Sulfate Hexasaccharide

      • Douglas M. Tollefsen

      Pages 167-176

   3. Thrombomodulin: An Anticoagulant Cell Surface Proteoglycan With Physiologically Relevant Glycosaminoglycan Moiety

      • John F. Parkinson, Takatoshi Koyama, Nils U. Bang, Klaus T. Preissner

      Pages 177-188

   4. The Interaction Between LACI and Heparin

      • George J. Broze Jr., Robin Wesselschmidt, Darryl Higuchi, Thomas Girard, Karen Likert, Louise MacPhail et al.

      Pages 189-197

This volume is a record of a meeting entitled "Heparin and Related Polysaccharides" that was held at the Biomedical Center, Uppsala, Sweden between 1-6 September 1991. The meeting was hosted by U. Lindahl, L. Kjellen and I. Bjork, who were helped in their preparations by a scientific advisory panel that included U. Abildgaard, B. Casu, E. Holmer and D. Lane. Altogether, 230 participants from 18 countries attended the meeting, and most were present to be included in a photograph, which is to be found at the end of this volume. The selection of presentations for inclusion in the Symposia of the meeting was made on the basis of the known high quality of the work of the individuals or groups involved. This, we believe, is reflected in the contents of the enclosed articles, which collectively give a comprehensive overview of the present state of knowledge of heparin and related compounds. Some of the areas covered are evolving or controversial and the views expressed in each article should be regarded as those of the author(s). The authors have taken various amounts of care to define all their abbreviations and some familiarity with the different forms of nomenclature used in the fields of polysaccharide chemistry and of the coagulation proteinases and their inhibitors will assist the reader.

• Activation
• Migration
• Polysaccharid
• Regulation
• Vivo
• enzymes
• metabolism
• plasma membrane

• Charing Cross and Westminster Medical School, London, UK

  David A. Lane

• The Swedish University of Agricultural Sciences, Uppsala, Sweden

  Ingemar Björk

• Uppsala University, Uppsala, Sweden

  Ulf Lindahl

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