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Intermediate Filaments as Markers of Neuronal Differentiation

  • Chapter
The Role of Cell Interactions in Early Neurogenesis

Part of the book series: NATO ASI Series ((NSSA,volume 77))

Abstract

Various polypeptides organized in fibrous networks forming microtubules, microfilaments and intermediate-filaments are implicated in axonal transport[1]. In the cytoplasm of all differentiated cells, each reseau is built with filaments constituted by a repeat of the same type of unit: ß and γ actins form microfilaments (diameter 70 Å), αß tubulin dimers polymerize in microtubules (diameter 250 Å) and one of the five polypeptide types autoasssembles to give intermediate sized filaments (diameter 80 to 140 Å). A variety of associated proteins are bound to the filaments with different affinities. Associated proteins could differ with the cell species conferring specific cell type properties.

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Author information

Authors and Affiliations

  1. Départment de Biologie moléculaire, Université Paris 7, 25 rue du Dr. Roux, 75015, Paris, France

    Fabienne Alfonsi, Michèle Darmon, Nadine Forest & Denise Paulin

  2. Départment de Biologie moléculaire, Institut Pasteur, 25 rue du Dr. Roux, 75015, Paris, France

    Michèle Darmon & Denise Paulin

Authors
  1. Fabienne Alfonsi
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  2. Michèle Darmon
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  3. Nadine Forest
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  4. Denise Paulin
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Editors and Affiliations

  1. Laboratory of General Biology, ERA—CNRS 327, Paul Sabatier University, Toulouse, France

    A.-M. Duprat

  2. University Medical Center, Geneva, Switzerland

    A. C. Kato

  3. Laboratory of Fundamental Pharmacology and Toxicology, LP—CNRS 8221, Toulouse, France

    M. Weber

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© 1984 Plenum Press, New York

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Alfonsi, F., Darmon, M., Forest, N., Paulin, D. (1984). Intermediate Filaments as Markers of Neuronal Differentiation. In: Duprat, AM., Kato, A.C., Weber, M. (eds) The Role of Cell Interactions in Early Neurogenesis. NATO ASI Series, vol 77. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1203-1_14

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  • DOI: https://doi.org/10.1007/978-1-4684-1203-1_14

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