Abstract
It has become clear that a quality of life assessment of anticancer treatment is crucial in measuring its impact. Quality of life assessment in cancers tends to assess side effects of treatment, usually chemotherapy, and therefore contains measures that are inappropriate for the majority of extremity sarcoma patients. Although it is important to measure emotional and social factors, physical factors are also crucial. The European Organization for Research and Treatment of Cancer (EORTC) QLQC30 is a commonly used measure that evaluates pain, fatigue, emotional functions, systemic symptoms, and physical functions [1]. About 40% of its questions assess physical function, but the total score is affected by measures that are not particularly relevant to extremity sarcoma patients. It is therefore not the most appropriate instrument in this group of patients.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aaronson NK, Bullinger M, Ahmedzai S. A modular approach to quality-of-life assessment in cancer clinical trials. Recent Results Cancer Res 111:231–249, 1988.
Abbatucci JS, Boulier N, De Ranieri J, Mandard AM, Tanguy A, Busson A. Radiotherapy as an integrated part of the treatment of soft tissue sarcomas. Radiother Oncol 2:115–121, 1984.
Eilber FR, Giuliano AE, Huth JF, Morton DL. A randomized prospective trial using postoperative adjuvant chemotherapy (Adriamycin) in high-grade extremity soft-tissue sarcoma. Am J Clin Oncol 11:39–45, 1988.
Potter DA, Kinsella T, Glatstein E, Wesley R, White DE, Seipp CA, Chang AE, Lack EE, Costa J, Rosenberg SA. High-grade soft tissue sarcomas of the extremities. Cancer 58:190–205, 1986.
Barkley HT, Jr., Martin RG, Romsdahl MM, Lindberg R, Zagars GK. Treatment of soft tissue sarcomas by preoperative irradiation and conservative surgical resection. Int J Radiat Oncol Biol Phys 14:693–699, 1988.
Suit HD, Mankin HJ, Wood WC, Gebhardt MC, Harman DC, Rosenberg A, Tepper JE, Rosenthal D. Treatment of the patient with stage Mo soft tissue sarcoma. J Clin Oncol 6:854–862, 1988.
Robinson M, Barr L, Fisher C, Fryatt I, Stotter A, Harmer C, Wiltshaw E, Westbury G. Treatment of extremity soft tissue sarcomas with surgery and radiotherapy. Radiother Oncol 18:221–233, 1990.
Ashby MA, Ago CT, Harmer CL. Hypofractionated radiotherapy for sarcomas. Int J Radiat Oncol Biol Phys 12:13–17, 1986.
Robinson MH, Spruce L, Eeles R, Fryatt I, Harmer CL, Thomas JM, Westbury G. Limb function following conservation treatment of adult soft tissue sarcoma. Eur J Cancer 27:1567–1574, 1991.
Chang AE, Steinberg SM, Culnane M, Lampert MH, Reggia AJ, Simpson CG, Hicks JE, White DE, Yang JJ, Glatstein E, Rosenberg SA. Functional and psychosocial effects of multimodality limb-sparing therapy in patients with soft tissue sarcomas. J Clin Oncol 7:1217–1228, 1989.
Sugarbaker PH, Barofsky I, Rosenberg SA, Gianola FJ. Quality of life assessment of patients in extremity sarcoma clinical trials. Surgery 91:17–23, 1982.
Pittam et al. Personal Communication.
Postma A, Kingma A, De-Ruiter JH, Koops HS, Veth RPH, Goeken LNH, Kamps WA, Karakousis CP. Quality of life in bone tumour patients comparing limb salvage and amputation of lower extremity. J Surg Oncol 51:47–51, 1992.
Christ GC. The psychosocial adaptation to bone cancer diagnsoed during adolescence: A long-term follow-up study. Diss Abstract Int A 53:2545, 1993.
Lampert MH, Gerber LH, Glatstein E, Rosenberg SA, Danoff JV. Soft tissue sarcoma: Functional outcome after wide local excision and radiation therapy. Arch Phys Med Rehabil 65:477–480, 1984.
Schipper H, Clinch J, McMurray A. Measuring the quality of life of cancer patients: The Functional Living Index-Cancer: Development and validation. J Clin Oncol 2:472–483, 1984.
Stinson SF, DeLaney TF, Greenberg J, Yang JC, Lampert MH, Hicks JE, Venzon D, White DE, Rosenberg SA, Glatstein EJ. Acute and long term effects on limb function of combined modality limb sparing therapy for extremity soft tissue sarcoma. Int J Radiat Oncol Biol Phys 21:1493–1499, 1991.
Bell RS, O’Sullivan B, Davis A, Langer F, Cummings B, Fornasier VL. Functional outcome in patients treated with surgery and irradiation for soft tissue tumours. J Surg Oncol 48:224–231, 1991.
Zelefsky MJ, Nori D, Shiu MH, Brennan MF. Limb salvage and soft tissue sarcomas involving neurovascular structures using combined surgical resection and brachytherapy. Int J Radiat Oncol Biol Phys 19:913–918, 1990.
Convery FR, Minteer MA, Amiel D, Connett KL. Polyarticular disability: Functional assessment. Arch Phys Med Rehabil 58:494–499, 1977.
Scranton J, Fogel ML, Erdman WR. II: Evaluation of functional levels of patients during and following rehabilitation. Arch Phys Med Rehabil 51:1–21, 1970.
Keus RB, Rutgers EJT, Ho GH, Gortzak E, Albus-Lutter CE, Hart AAM. Limb sparing therapy of extremity soft tissue sarcomas: Treatment outcome and long-term functional results. Eur J Cancer 30A:10:1459–1463, 1994.
Johnstone PA, Wexler LH, Venzon DJ, Jacobson J, Yang JC, Horowitz ME, DeLaney TF. Sarcomas of the hand and foot: Analysis of local control and functional result with combined modality therapy in extremity preservation. Int J Radiat Oncol Biol Phys 29:735–745, 1994.
Okunieff P, Suit HT, Proppe KH. Extremity preservation by combined modality treatment of sarcomas of the hand and wrist. Int J Oncol Biol Phys 12:1923–1929, 1986.
Talbert ML, Zagars GK, Sherman NE, Romsdahl MM. Conservative surgery and radiation therapy for soft tissue sarcoma of the wrist, hand, ankle, and foot. Cancer 66:2482–2491, 1990.
Selch MT, Kopald KH, Ferreiro GA, Mirra JM, Parker RG, Eilber FR. Limb salvage therapy for soft tissue sarcomas of the foot. Int J Radiat Oncol Biol Phys 19(Suppl 1):124, 1990.
Pitcher ME, Thomas JM. Functional compartmental resection for soft tissue sarcomas. Eur J Surg Oncol 20:441–445, 1994.
Peat BG, Bell RS, Davis A, O’Sullivan B, Mahoney J, Manktelow RT, Bowen V, Catton C, Fornasier VL, Langer F. Wound-healing complications after soft-tissue sarcoma surgery. Plast Reconstr Surg 93:980–987, 1994.
Saddegh MK, Bauer HC. Wound complication in surgery of soft tissue sarcoma. Analysis of 103 consecutive patients managed without adjuvant therapy. Clin Orthopaed 289:247–253, 1993.
Arbeit JM, Lees DE, Corsey R, Brennan MF. Resting energy expenditure in controls and cancer patients with localized and diffuse disease. Ann Surg 199:292–298, 1984.
Nielsen OS, Cummings B, O’Sullivan B, Catton C, Bell RS, Fornasier VL. Preoperative and postoperative irradiation of soft tissue sarcomas: Effect on radiation field size. Int J Radiat Oncol Biol Phys 21:1595–1599, 1991.
Karasek K, Constine LS, Rosier R. Sarcoma therapy: Functional outcome and relationship to treatment parameters. Int J Radiat Oncol Biol Phys 24:651–656, 1992.
Weddington WW. Psychological outcomes in survivors of extremity sarcomas following amputation or limb-sparing surgery. Cancer Treat Res 56:53–60, 1991.
Lampert MH, Gahagen C. Physical therapy for the cancer patient. In CL McGarvey, ed. Rehabilitation of the Sarcoma Patient. Clinics in Physical Therapy. New York: Churchill Livingstone, 1990:111–135.
Ball ABS, Fisher C, Pittam M, Watkins RM, Westbury G. Diagnosis of soft tissue tumours by Tru-CutR biopsy. Br J Surg 77:756–758, 1990.
Stotter AT, A’Hern RP, Fisher C, Mott AF, Fallowfield ME, Westbury G. The influence of local recurrence of extremity soft tissue sarcoma on metastasis and survival. Cancer 66:1119–1129, 1990.
Light KL. Immobilisation and treatment of patients receiving radiation therapy for extremity soft tissue sarcoma. Med Dosim 17:135–139, 1992.
Schraffordt-Koops H, Lienard D, Eggermont AM, Hoekstra HJ, VanGeel BN, Lejeune FJ. Isolated limb perfusion with high-dose TNF-alpha, gamma-IFN, and mephalan in patients with unresectable soft tissue sarcomas: A highly effective limb-sparing procedure. Society of Surgical Oncology, 46th Annual Cancer Symposium in Conjunction with Society of Head and Neck Surgeons March, 1993, Los Angeles, CA, p 1.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media New York
About this chapter
Cite this chapter
Robinson, M.H. (1997). Post-treatment limb function in soft tissue sarcomas. In: Verweij, J., Pinedo, H.M., Suit, H.D. (eds) Soft Tissue Sarcomas: Present Achievements and Future Prospects. Cancer Treatment and Research, vol 91. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6121-7_6
Download citation
DOI: https://doi.org/10.1007/978-1-4615-6121-7_6
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7805-1
Online ISBN: 978-1-4615-6121-7
eBook Packages: Springer Book Archive