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A Modular Approach to Quality-of-Life Assessment in Cancer Clinical Trials

  • Conference paper
Cancer Clinical Trials

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 111))

Abstract

Cancer clinical trials focus upon the evaluation of such biomedical outcomes as duration of survival, retardation of the disease process and control of major physical symptoms (Buyse et al. 1984; Friedman et al. 1985). In recent years, however, these clinical end points have been criticized for a lack of comprehensiveness (Greer 1984; Greer and Silberfarb 1982). Following the lead of the WHO in defining health as complete physical, mental and social well-being, the scope of investigation has been extended to include assessment of a range of psychosocial variables that can be subsumed under the heading “quality of life.”

The research described in this paper is a project of the EORTC Study Group on Quality of Life (protocol 15861). The study coordinator is N. K. Aaronson. The national coordinators are: P.B.C.Rofe (Australia), B.Pfausler (Austria), D.Razavi (Belgium), D.Osoba (Canada), M. Bullinger (Federal Republic of Germany), S. Schraub (France), S. Ahmedzai (United Kingdom), A.Filiberti (Italy), F.Takeda (Japan), J.C.J.M. de Haes (the Netherlands), S. Kaasa (Norway), J. Estape (Spain), M. Sullivan (Sweden), J. Bernhard (Switzerland), and M.Mastilica (Yugoslavia). O.Dalesio and D.Crabeels are, respectively, the EORTC Data Center statistician and data manager associated with the project.

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References

  • Aaronson NK (1986) Methodological issues in psychological oncology with special reference to clinical trials. In: Ventafridda V, van Dam FSAM, Yancik R, Tamburini M (eds) Assessment of quality of life and cancer treatment. Elsevier Science, Amsterdam, pp 29–41

    Google Scholar 

  • Aaronson NK (study coordinator) (1987) EORTC protocol 15861: development of a core quality-of-life questionnaire for use in cancer clinical trials. EORTC Data Center, Brussels

    Google Scholar 

  • Aaronson NK, Bakker W, Stewart Al, van Dam FSAM, van Zandwijk N, Yarnold JR, Kirk-patrick A (1987) Multidimensional approach to the measurement of quality of life in lung cancer clinical trials. In: Aaronson N, Beckmann J (eds) The quality of life of cancer patients. Raven, New York, pp 63–82

    Google Scholar 

  • American Psychological Association (1974) Standards for educational and psychological tests. APA, Washington, DC

    Google Scholar 

  • Andersen BL (1985) Sexual functioning morbidity among cancer survivors: current status and future research directions. Cancer 55(8): 1835–1842

    Article  PubMed  CAS  Google Scholar 

  • Bardelli D, Saracci R (1978) Measuring the quality of life in cancer clinical trials: a sample survey of published trials. UICC technical report series, Geneva

    Google Scholar 

  • Bergner M, Bobbit RA, Carter WB, Gilson BS (1981) The Sickness Impact Profile: development and final revision of a health status measure. Med Care 19: 787–805

    Article  PubMed  CAS  Google Scholar 

  • Bury M (1982) Chronic illness as biographical disruption. Sociology Health Illness 41: 167–182

    Article  Google Scholar 

  • Buyse ME, Staquet MJ, Sylvester RJ (eds) (1984) Cancer clinical trials. Oxford University Press, Oxford

    Google Scholar 

  • Campbell DT, Fiske DW (1959) Convergent and discriminant validation by the multitrait-multimethod matrix. Psychol Bull 56: 81–105

    Article  PubMed  CAS  Google Scholar 

  • Chambers LW, MacDonald LA, Tugwell P (1983) The McMaster health index questionnaire as a measure of quality of life for patients with rheumatoid arthritis. J Rheumatol 9: 780–784

    Google Scholar 

  • Ciampi A, Silberfeld M, Till JE (1983) Health status indices: some approaches and their limitations for oncology. Int Psychol 15: 4–14

    Google Scholar 

  • Clark A, Fallowfield LJ (1986) Quality-of-life measurements in patients with malignant disease: a review. J R Soc Med 79(3): 165–169

    PubMed  CAS  Google Scholar 

  • Cronbach LJ (1951) Coefficient alpha and the internal structure of tests. Psychometrika 16: 297–334

    Article  Google Scholar 

  • Daut RL, Cleeland CS (1982) The prevalence and severity of pain in cancer. Cancer 50: 1913–1918

    Article  PubMed  CAS  Google Scholar 

  • de Haes JCJM, van Knippenberg FCE (1985) The quality of life of cancer patients: a review of the literature. Soc Sci Med 20: 809–817

    Article  PubMed  Google Scholar 

  • Derogatis LR, Morrow GR, Fetting J, Penman D (1983) The prevalence of psychiatric disorders among cancer patients. JAMA 249: 751–757

    Article  PubMed  CAS  Google Scholar 

  • DuPuy HJ (1984) The psychological general well-being (PGWB) index. In: Wenger NK, Mattsen ME, Furberg CD, Ellinson J (eds) Assessment of quality of life in clinical trials of cardiovascular therapies. Le Jacq, Washington, DC, pp 170–184

    Google Scholar 

  • Endicott J (1984) Measurement of depresssion in patients with cancer. Cancer 53: 2243–2248

    PubMed  CAS  Google Scholar 

  • Fayers PM, Jones DR (1983) Measuring and analysing quality of life in cancer clinical trials: a review. Stat Med 2: 429–446

    Article  PubMed  CAS  Google Scholar 

  • Friedman LM, Furberg CD, DeMets DL (1985) Fundamentals of clinical trials. PSG, New York

    Google Scholar 

  • Gottschalk LA (1983) Measurement of mood and affect in cancer patients. Cancer 53 [Suppl]: 2236–2240

    Google Scholar 

  • Gough IR, Furnival CM, Schilder L, Grove W (1983) Assessment of the quality of life of patients with advanced cancer. Eur J Cancer Clin Oncol 19: 1161–1165

    Article  PubMed  CAS  Google Scholar 

  • Green S, Silberfarb PM (1982) Psychological concomitants of cancer: current state of research. Psychol Med 12: 563–573

    Article  Google Scholar 

  • Greenwald HP (1987) The specificity of quality-of-life measures among the seriously ill. Med Care 25: 642–651

    Article  PubMed  CAS  Google Scholar 

  • Greer DS (1987) Quality-of-life measurement in the clinical realm. J Chronic Dis 40: 629

    Article  PubMed  CAS  Google Scholar 

  • Gréer S (1984) The psychological dimension in cancer treatment. Soc Sci Med 18(4): 345–349

    Article  PubMed  Google Scholar 

  • Guttman LA (1944) A basis for scaling qualitative data. Am Soc Rev 9: 139–150

    Article  Google Scholar 

  • Helmstadter CG (1964) Principles of psychological measurement. Appleton-Century-Crofts, New York

    Google Scholar 

  • Hunt SM, McWeen J, McKenna SP (1981) The Nottingham Health Profile: subjective health status and medical consultations. Soc Sci Med [A] 15: 221–229

    CAS  Google Scholar 

  • Hutchinson TA, Boyd NF, Feinstein AR (1979) Scientific problems in clinical scales as demonstrated in the Karnofksy Index of performance status. J Chronic Dis 32: 661–666

    Article  PubMed  CAS  Google Scholar 

  • Kaplan M, Bush J (1982) Health-related quality-of-life measurement for evaluation research and policy analysis. Health Psychol 1: 61–80

    Article  Google Scholar 

  • Katz S (1987) The science of quality of life. J Chronic Dis 40: 459

    Article  PubMed  CAS  Google Scholar 

  • Krauth J (1982) Objective measurements of the quality of life. Experientia 41: 402–451

    CAS  Google Scholar 

  • Lane DA (1987) Utility, decision and quality of life. J Chronic Dis 40: 585

    Article  PubMed  CAS  Google Scholar 

  • Likert R (1932) A technique for the measurement of attitudes. Arch Psychol 140:1–55

    Google Scholar 

  • Linssen ACG, Hanewald G, van Dam FSAM, van Beek-Couzijn AL (1981) The development of the “complaint questionnaire” at the Netherlands Cancer Institute. In: Proc 1st EORTC study group on quality of life workshop, Amsterdam, 22-23 May 1981

    Google Scholar 

  • Meenan RF (1980) Measuring health status in arthritis: the arthritis impact measurement scale. Arthritis Rheum 23: 146–152

    Article  PubMed  CAS  Google Scholar 

  • Nie NH, Hull CH, Jenkins JG, Steinbrenner K, Bent DH (1970) Statistical package for the social sciences, 2nd edn. McGraw Hill, New York

    Google Scholar 

  • Nunnally JC (1978) Psychometric theory, 2nd edn. McGraw Hill, New York

    Google Scholar 

  • Schipper H, Clinch J, McMurray A, Levitt M (1984) Measuring the quality of life of cancer patients: the functional living index cancer. J Clin Oncol 2: 472–483

    PubMed  CAS  Google Scholar 

  • Selby PJ, Chapman JAW, Etazadi-Amoli J, Dalley D, Boyd NF (1984) The development of a method of assessing the quality of life of cancer patients. Br J Cancer 50: 13–22

    Article  PubMed  CAS  Google Scholar 

  • Stewart Al, Ware JE, Brook RH (1982) Constructing and scoring of aggregate functional status measures, vol 1, R-2551-1-HHS. Rand Corporation, Santa Monica, CA

    Google Scholar 

  • van Dam FSAM, Linssen CAG, Couzijn AL (1984) Evaluating quality of life in cancer clinical trials. In: Buyse H et al. (eds) Cancer clinical trials: methods and practice. Oxford University Press, Oxford, pp 26–46

    Google Scholar 

  • Ware JE (1984a) Methodology in behavioral and psychological cancer research: conceptualizing disease impact and treatment outcomes. Cancer 53 [Suppl]: 2316–2326

    PubMed  Google Scholar 

  • Ware JE (1984b) Methodological considerations in the selection of health status assessment procedures. In: Wenger NK, Mattson ME, Furberg CD, Elinson J (eds) Assessment of quality of life in cardiovascular clinical trials. Le Jacq, Washington, DC, pp 87–112

    Google Scholar 

  • Ware JE (1987) Standards for validating health measures: definition and content. J Chronic Dis 40: 473ff

    Article  PubMed  Google Scholar 

  • Ware JE, Davies-Avery A, Donald CA (1978) Conceptualization and measurement of health for adults in the health insurance study, vol 5. Rand Corporation, Santa Monica, CA

    Google Scholar 

  • Wood-Dauphinee S, Troidl H (1986) End points for surgical clinical studies: conventional and innovative variables. In: Troidl H, Spitzer WO, McPeek B, Mulder DS, McKneally MA (eds) Principles and practice of research. Springer, Berlin Heidelberg New York, pp 54–68

    Google Scholar 

  • Wortman CB (1983) Social support and the cancer patient: conceptual and methodological issues. Cancer 53: 2217–2384

    Google Scholar 

  • Zigmond AS, Snaith RP (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67: 3661–3670

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

    N. K. Aaronson, M. Bullinger & S. Ahmedzai

Authors
  1. N. K. Aaronson
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  2. M. Bullinger
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  3. S. Ahmedzai
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Editor information

Editors and Affiliations

  1. Institut für Medizinische Biometrie und Informatik, Universität Heidelberg, Im Neuenheimer Feld 325, 6900, Heidelberg, Germany

    Hans Scheurlen

  2. Department of Probability and Statistics, University of Sheffield, Sheffield, S3 7RH, Great Britain

    Richard Kay

  3. King’s College, School of Medicine and Dentistry, CRC Clinical Trials Centre, Rayne Institute, 123 Coldharbour Lane, London, SE5 9NU, Great Britain

    Michael Baum

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© 1988 Springer-Verlag Berlin · Heidelberg

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Aaronson, N.K., Bullinger, M., Ahmedzai, S. (1988). A Modular Approach to Quality-of-Life Assessment in Cancer Clinical Trials. In: Scheurlen, H., Kay, R., Baum, M. (eds) Cancer Clinical Trials. Recent Results in Cancer Research, vol 111. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83419-6_27

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  • DOI: https://doi.org/10.1007/978-3-642-83419-6_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83421-9

  • Online ISBN: 978-3-642-83419-6

  • eBook Packages: Springer Book Archive

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