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Metal Ion Stress in Yeast

  • Chapter
Metal Ions in Gene Regulation

Part of the book series: Chapman & Hall Microbiology Series ((CHMBS))

Abstract

It is well known that metal ions are essential for normal physiology. At least 16 metal ions are known to be essential for life. The implication of being essential is that an optimal, intracellular concentration of each particular metal ion is required for homeostasis. Reduced concentrations cause reduced growth as a result of metal ion deficiency, and excess concentrations can cause metal-induced toxicity (Figure 11.1). The key issue is the intracellular concentration of available metal ions, which are likely to be present as metal complexes with dissociable ligands. Concentrations of available metal ions above or below a threshold value may evoke a variety of coordinated physiological responses that compensate for environmental changes to inadequate or excess metal ion concentrations. Although homeostasis can be maintained over a limited range of metal ion concentrations, extreme conditions of low or high concentrations in the environment or diet can result in impaired physiology (Figure 11.1). Deficiency of an essential metal ion may impair physiology through loss of critical enzymatic functions of metalloenzymes. Excessive metal concentrations may affect cellular metabolism in many ways, including disruption of cell membrane integrity, alteration of the cellular redox state, and inhibition of respiration. DNA replication, or protein synthesis (Ochai 1987; Gadd and White 1989; Agarwal et al. 1989). These toxic effects may arise from direct inhibition of protein function or indirect mechanisms such as metal-induced initiation of free radical reactions (Halliwell et al. 1988).

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  1. Dennis R. Winge
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  2. Andrew K. Sewell
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  4. Joanne L. Thorvaldsen
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Winge, D.R., Sewell, A.K., Yu, W., Thorvaldsen, J.L., Farrell, R. (1998). Metal Ion Stress in Yeast. In: Silver, S., Walden, W. (eds) Metal Ions in Gene Regulation. Chapman & Hall Microbiology Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5993-1_11

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