Skip to main content

Ontogenesis and Expression of ALDH Activity in the Skin and the Eye of the Rat

  • Chapter
Enzymology and Molecular Biology of Carbonyl Metabolism 6

Abstract

As the body’s first line of defense against external insult, both the eye and the skin are exposed routinely to chemical agents, serving as a portal of entry for topical contactants. In addition, global atmospheric changes like ozone depletion in the stratosphere contribute to enhanced chronic exposure of the skin and the eye of human tissue to UV light (Hendee, 1989). The hazardous effects of UV light on the eye were already recognized in 1920 by van der Hoeve. By the 1920s, basal cell carcinomas of the skin were also noted.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Boesch, J.S., Lee, C. and Lindahl, R.: Constitutive expression of class 3 aldehyde dehydrogenase in cultured rat corneal epithelium. J. Biol. Chem. 271 (1996) 5150–5157.

    Article  PubMed  CAS  Google Scholar 

  • Burke, M.D. and Mayer, R.T.: Inherent specificities of purified cytochromes P-450 and P-448 toward biphenyl hydroxylation and ethoxyresorufin deethylation. Drug Metab.Dispos. 3 (1975) 245–253.

    PubMed  CAS  Google Scholar 

  • Chen, M., Achkar, C. and Gudas, L.J.: Enzymatic conversion of retinaldehyde to retinoic acid by cloned murine cytosolic and mitochondrial aldehyde dehydrogenases. Mol.Pharmacol. 46 (1994) 88–96.

    PubMed  CAS  Google Scholar 

  • Cross, C.E., Halliwell, B., Borish, E.T., Pryor, W., Ames, B.N., Saul, R.L., McCord, J.M. and Harman, D.: Oxygen radicals in human disease. Ann.Intern.Med. 107 (1987) 526–545.

    Article  PubMed  CAS  Google Scholar 

  • Deitrich, R.A.: Tissue and subcellular distribution of mammalian aldehyde-oxidazing capacity. Biochem. Pharmacol. 15 (1966) 1911–1922.

    Article  PubMed  CAS  Google Scholar 

  • Deitrich, R.A.: Genetic aspects of increase in rat liver aldehyde dehydrogenase induced by phenobarbital. Science 173 (1971) 334–336.

    Article  PubMed  CAS  Google Scholar 

  • Dockham, P.A., Lee, M.O. and Sladek, N.E.: Identification of human liver aldehyde dehydrogenases that catalyze the oxidation of aldophosphamide and retinaldehyde. Biochem.Pharmacol. 43 (1992) 2453–2469.

    Article  PubMed  CAS  Google Scholar 

  • Downes, J. and Holmes, R.: Development of aldehyde dehydrogenase and alcohol dehydrogenase in mouse eye: Evidence for light-induced changes. Biol.Neonate 61 (1992) 118–123.

    Article  PubMed  CAS  Google Scholar 

  • Dunn, T.J., Lindahl, R. and Pitot, H.C.: Differential gene expression to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Noncoordinate regulation of a TCDD-induced aldehyde dehydrogenase and cytochrome P-450c in the rat. J. Biol. Chem. 263 (1988) 10878–10886.

    PubMed  CAS  Google Scholar 

  • Esterbauer, H., Schaur, R.J. and Zollner, H.: Chemistry and biochemistry of 4-hydroxynonenal malondialdehyde and related aldehydes. FreeRad.Biol.Med. 11 (1991) 81–128.

    Article  CAS  Google Scholar 

  • Godbout, R.: Identification and characterization of transcripts present at elevated levels in the undifferentiated chick retina. Exp.EyeRes. 56 (1993) 95–106.

    CAS  Google Scholar 

  • Gornall, A.G., Bardawill, C.J. and David, M.M.: Determination of serum proteins by means of the biuret reaction. J. Biol. Chem. 177 (1949) 751–766.

    PubMed  CAS  Google Scholar 

  • Habig, W.H., Pabst, M.J. and Jakoby, W.B.: Glutathione-S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249 (1974) 7130–7139.

    PubMed  CAS  Google Scholar 

  • Hendee, W.R.: Harmful effects of ultraviolet radiation. J. Am. Med. Assoc. 262 (1989) 380–384.

    Article  Google Scholar 

  • Lindahl, R. and Petersen, D.R.: Lipid aldehyde oxidation as physiological role for class 3 aldehyde dehydrogenases. Biochem Pharmacol 41 (1991) 1583–1587.

    Article  PubMed  CAS  Google Scholar 

  • Lindahl, R.: Aldehyde dehydrogenases and their role in carcinogenesis. CRC Crit.Rev.Biochem.Mol.Biol. 27 (1992) 283–335.

    Article  CAS  Google Scholar 

  • Lee, M.O., Manthey, C.L. and Sladek, N.E.: Identification of mouse liver aldehyde dehydrogenases that catalyze the oxidation of retinaldehyde to retinoic acid. Biochem.Pharmacol. 42 (1991) 1279–1285.

    Article  PubMed  CAS  Google Scholar 

  • Marks-Hull, H., Shiao, T-Y., Araki-Sasaki, K., Traver, R. and Vasiliou, V.: Expression of ALDH3 and NMO1 in human corneal epithelial and breast adenocarcinoma cells. Adv.Exp.Med.Biol. (1997) in press.

    Google Scholar 

  • Marselos, M.: Genetic variation of drug metabolizing enzymes in the Wistar rat. Acta Pharmacol.Toxicol. 39 (1976) 186–197.

    Article  CAS  Google Scholar 

  • Marselos, M., Torronen, R., Koivoula, T. and Koivusalo, M.: Comparison of phenobarbital and carcinogen-induced aldehyde dehydrogenases in the rat. Biochem.Pharmacol. 27 (1979) 110–118.

    Google Scholar 

  • Marselos, M. and Lindahl, R.: Substrate preference of a cytosolic aldehyde dehydrogenase inducible in rat liver by treatment with 3-methylcholanthrene. Toxicol Appl Pharmacol 95 (1988) 339–345.

    Article  PubMed  CAS  Google Scholar 

  • Marselos, M. and Vasiliou, V.: Effect of various chemicals on the aldehyde dehydrogenase activity of the rat liver cytosol. Chem-Biol.Interact. 79 (1991) 79–89.

    Article  PubMed  CAS  Google Scholar 

  • Marx, J.L.: Oxygen free radicals linked to many diseases. Science 235 (1987) 529–531.

    Article  PubMed  CAS  Google Scholar 

  • McCaffery, P., Tempst, P., Lara, G. and Drager, U.: Aldehyde dehydrogenase is a posiional marker in the retina. Development 112 (1991) 693–702.

    PubMed  CAS  Google Scholar 

  • McCammon, D.K., Zhou, P., Turney, M.K., McPhaul, M.J. and Kovacs, W.J.: An androgenic affinity ligand cova-lently binds to cytosolic aldehyde dehydrogenase from human genital skin fibroblasts. Mol.Cellul.Endocr. 91 (1993) 177–183.

    Article  CAS  Google Scholar 

  • Nebert, D.W. and Gonzalez, F.J.: P450 genes: Structure, evolution and regulation. Annu.Rev.Biochem. 56 (1987) 945–993.

    Article  PubMed  CAS  Google Scholar 

  • Nebert, D.W., Puga, A. and Vasiliou, V.: Role of Ah receptor and the dioxin-inducible [Ah] gene battery in toxicity, cancer and signal transduction. Ann.N.Y.Acad.Sci. 685 (1993) 624–640.

    Article  PubMed  CAS  Google Scholar 

  • Pappas, P., Vasiliou, V., Karageorgou, M., Stefanou, P. and Marselos, M.: Studies on the induction of rat class 3 aldehyde dehydrogenase. Adv.Exp.Med.Biol. 372 (1995) 143–149.

    Article  PubMed  CAS  Google Scholar 

  • Saari, J.C., Champer, R.J., Asson-Batres, M.A., Garwin, G.G., Huang, J., Crabb, J.W. and Milam, A.H.: Characterization and localization of an aldehyde dehydrogenase to amacrine cells of bovine retina. Visual Neuroscience 12 (1995) 263–272.

    Article  PubMed  CAS  Google Scholar 

  • Sladek, N.E. and Lee, M.O.: The use of immortalized mouse L1210/OAP cells established in culture to study the major class 1 aldehyde dehydrogenase-catalyzed oxidation of aldehydes in intact cells. Adv.Exp.Med.Biol. 328 (1993) 51–62.

    Article  PubMed  CAS  Google Scholar 

  • Swanson, H.I., and Bradfield, C.A.: The AH receptor: genetics, structure and function. Pharmacogenetics 3 (1993) 213–230.

    Article  PubMed  CAS  Google Scholar 

  • Taylor, B.A.: Strain distribution and linkage tests of 7,12-dimethylbenzanthracene (DMBA) inflammatory response in mice. Life Sci. 10 (1971) 1127–1134.

    Article  CAS  Google Scholar 

  • Torronen, R., Nousiainen, U. and Hanninen, O.: Induction of aldehyde dehydrogenase activity by polycyclic aromatic hydrocarbons. Chem-Biol.Interact. 36 (1981) 33–34.

    Article  PubMed  CAS  Google Scholar 

  • Vasiliou, V.: Effect of various chemicals on ALDH activities in the Wistar rat. Ph.D. Thesis, University of Ioannina, Greece, 1988.

    Google Scholar 

  • Vasiliou, V. and Marselos, M.: Tissue distribution of inducible aldehyde dehydrogenase activity in the rat after treatment with phenobarbital or methylcholanthrene. Pharmacol.Toxicol. 64 (1989) 39–42.

    Article  PubMed  CAS  Google Scholar 

  • Vasiliou, V., Puga, A. and Nebert, D.W.: Negative regulation of the murine cytosolic aldehyde dehydrogenase-3 (Aldh-3c) gene by functional CYP1A1 and CYP1A2 proteins. Biochem.Biophys.Res.Commun. 187 (1992) 413–419.

    Article  PubMed  CAS  Google Scholar 

  • Vasiliou, V., Puga, A. and Nebert, D.W.: Mouse class 3 aldehyde dehydrogenases: Positive and negative regulation in gene expression. Advanc. Exp. Med. Biol. 4 (1993) 131–139.

    Article  Google Scholar 

  • Vasiliou, V., Weiner, H., Marselos, M. and Nebert, D.W.: Mammalian aldehyde dehydrogenase genes: clasification based on evolution, structure and regulation. Eur. J. Drug Metab. Pharmacokinet. 20 (1995) 53–64.

    CAS  Google Scholar 

  • Westlund, P., Fylling, A.C., Cederlund, E. and Jornvall, H.: 11-Hydroxythromboxane B2 dehydrogenase is identical to cytosolic aldehyde dehydrogenase. FEBS Lett. 345 (1994) 99–103.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer Science+Business Media New York

About this chapter

Cite this chapter

Pappas, P., Stephanou, P., Vasiliou, V., Karamanakos, P., Marselos, M. (1996). Ontogenesis and Expression of ALDH Activity in the Skin and the Eye of the Rat. In: Weiner, H., Lindahl, R., Crabb, D.W., Flynn, T.G. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 6. Advances in Experimental Medicine and Biology, vol 414. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5871-2_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-5871-2_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7692-7

  • Online ISBN: 978-1-4615-5871-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics