Abstract
A Class 3 aldehyde dehydrogenase (ALDH3c; EC 1.2.1.3), present in rat liver cytosol is highly inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or polycyclic hydrocarbons such as 3-methylcholanthrene (3MC) and aromatic amines (Törrönen et al., 1981; Vasiliou et al, 1988; Marselos and Vasiliou, 1991). Induction of ALDH3c has also been observed in a number of extrahepatic rat tissues including lungs, spleen, urinary bladder, heart, and brain (Dunn et al., 1988; Vasiliou and Marselos, 1989). Induction of ALDH3c by either TCDD or 3MC has also been found in cultures of human hepatoma cell lines (HepG2), normal human hepatocytes, mouse and rat hepatoma cells and (Marselos et al., 1987; Vasiliou et al., 1992, 1993a). This induction process requires a functional aromatic hydrocarbon (Ah) receptor present in the cytosol (Vasiliou et al., 1992; 1993a; Nebert et al., 1993). After binding, the inducer-receptor complex translocates into the nucleus, forms a heterodimer with the Ah receptor nuclear translocator (ARNT), and binds to one or more aromatic hydrocarbon-responsive elements (AhREs) identified upstream of murine and rat ALDH3c genes (Asman et al., 1993; Vasiliou et al., 1994). In this chapter, we address questions regarding possible parameters regulating the induction of rat liver ALDH3c by 3MC., such as (i) glutathione depletion, (ii) sex hormones, (iii) non steroid anti-inflammatory drugs (NSAIDs) and (iv) the overall drug metabolizing capacity.
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Pappas, P., Vasiliou, V., Karageorgou, M., Stefanou, P., Marselos, M. (1995). Studies on the Induction of Rat Class 3 Aldehyde Dehydrogenase. In: Weiner, H., Holmes, R.S., Wermuth, B. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 5. Advances in Experimental Medicine and Biology, vol 372. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1965-2_19
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DOI: https://doi.org/10.1007/978-1-4615-1965-2_19
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