Abstract
Malignant tumors are the result of unregulated growth of a “tumorigenic cell” which proliferates without respecting; a) its own regulatory mechanisms (failure of autocrine regulation), b) cell-cell interactions with adjacent cells (failure of paracrine regulation), and c) systemic regulatory mechanisms (failure of hormonal regulation).
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Koutsilieris, M., Rogers, P.A. (1994). The Role of Plasma Membrane in the Pathogenesis of Osteoblastic Metastasis. In: Bkaily, G. (eds) Membrane Physiopathology. Developments in Cardiovascular Medicine, vol 159. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2616-2_21
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DOI: https://doi.org/10.1007/978-1-4615-2616-2_21
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