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Interleukins

Molecular and Biological Characteristics

  • Chapter
Immunology of Rheumatic Diseases

Abstract

Lymphocyte reactions are complex and involve interactions between lymphocyte subsets and accessory cells and a number of soluble molecules that they produce. A major contribution to the study of T-cell biology was provided by the observations of Morgan et al. (1976) that a cytokine, then designated as T-cell growth factor (TCGF), released into conditioned media of lectin-stimulated mononuclear cells could support the long-term growth of T cells in a culture system. This has led to the development of homogeneous clones of various T-cell subsets that permitted functional studies of T-cell subsets, their capacity to produce various effector and immunoregulatory molecules, mechanisms of interactions with various growth and inhibitory factors, and requirement for various molecules for their own growth.

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  1. Department of Medicine, Division of Basic and Clinical Immunology, University of California, Irvine, California, 92717, USA

    Sudhir Gupta

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  1. College of Medicine, University of California, Irvine, California, USA

    Sudhir Gupta M.D.,F.R.C.P.(C), F.A.C.P.

  2. Health Science Center, University of Texas, San Antonio, Texas, USA

    Norman Talal M.D.

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Gupta, S. (1985). Interleukins. In: Gupta, S., Talal, N. (eds) Immunology of Rheumatic Diseases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2493-5_4

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