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Pathogenesis of Murine Spongiform Myeloencephalopathy Induced by a Murine Retrovirus

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Molecular Neurovirology

Abstract

Most retroviruses isolated to date from various animal species induce neoplasia in vivo or cell transformation in vitro. They appear to do so by mimicking, perturbing, or utilizing unique signal-transducing pathways of the cell. A few of these viruses (visna [1], caprine arthritis encephalitis virus [2], equine infectious anemia virus [3], and simian immunodeficiency virus [4]) induce inflammatory neurological diseases (encephalitis and myelitis), and some murine leukemia virus (MuLV) isolates (5–7) induce a noninflammatory spongiform myeloencephalopathy. Interestingly, among the few retroviruses inducing disease in humans, two, human immunodeficiency virus-1 (HIV-1) (8) and human T-cell lymphotropic virus-1 (HTLV-1) (9), have been found to be associated with a severe neurological disease. Most likely, the animal models of retrovirus-induced neurological diseases will provide insight into the pathogenesis of these human diseases apparently induced by human retroviruses. In addition, because of the way retroviruses interact with their host target cells, these animal models may also be instrumental in probing the mechanism(s) of neuronal loss in other human neurodegenerative diseases, even those that are not induced by a retrovirus.

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Authors
  1. Paul Jolicoeur
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  2. Claude Gravel
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  3. Denis G. Kay
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  1. University of Chicago Medical Center, Chicago, Illinois, USA

    Raymond P. Roos

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Jolicoeur, P., Gravel, C., Kay, D.G. (1992). Pathogenesis of Murine Spongiform Myeloencephalopathy Induced by a Murine Retrovirus. In: Roos, R.P. (eds) Molecular Neurovirology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0407-7_4

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  • DOI: https://doi.org/10.1007/978-1-4612-0407-7_4

  • Publisher Name: Humana Press, Totowa, NJ

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