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Stress-activated Protein Kinase Signaling in Drosophila

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Stress-Activated Protein Kinases

Part of the book series: Topics in Current Genetics ((TCG,volume 20))

Abstract

Genetic analyses in Drosophila have shown that the components of the Stress-Activated Protein Kinase (SAPK) pathways are structurally and functionally conserved in this organism. The genetic tractability of the fruit fly has facilitated in vivo analyses of SAPK signaling that would have been exceedingly difficult to carry out in mammalian systems. This approach has yielded important new knowledge about the in vivo functions of JNK in development, wound healing, innate immunity, developmental and TNF-mediated apoptosis, oxidative stress resistance and lifespan regulation. Similarly, the Drosophila p38 pathway appears to be involved in development, immunity, and stress response, but more research is needed to fully understand its components and functions. It is anticipated that genetic approaches in Drosophila will continue to produce novel insights into SAPK signaling that are directly relevant to rodent models and humans.

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  1. Department of Biomedical Genetics, University of Rochester Medical Center, 14642, Rochester, NY, USA

    Gerasimos P. Sykiotis & Dirk Bohmann

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  1. Gerasimos P. Sykiotis
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Correspondence to Dirk Bohmann .

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Francesc Posas Angel R. Nebreda

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Sykiotis, G.P., Bohmann, D. (2007). Stress-activated Protein Kinase Signaling in Drosophila . In: Posas, F., Nebreda, A.R. (eds) Stress-Activated Protein Kinases. Topics in Current Genetics, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/4735_2007_0251

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