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Electrospun Janus core (ethyl cellulose//polyethylene oxide) @ shell (hydroxypropyl methyl cellulose acetate succinate) hybrids for an enhanced colon-targeted prolonged drug absorbance

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Abstract

Structural polymeric nanohybrids is presently a popular topic and can be conceived for numerous functional applications, including the pH-sensitive oral colon-targeted drug-delivery system. In this paper, a brand-new Janus core@shell (JCS) nanostructure was fabricated using a trifluid electrospinning, in which three polymers and a model drug 5-fluorouracil (5-FU) were elaborately and intentionally positioned. In the structural hybrids, the pH-sensitive polymer hydroxypropyl methyl cellulose acetate succinate was located in the common shell layer, and the 5-FU-loaded ethyl cellulose (EC) and polyethylene oxide (PEO) were organized in a side-by-side manner in the core sections. The JCS fiber had a fine linear morphology with a multiple-chamber structure and a shell thickness of about 24 nm. The drug presented in the fibers in an amorphous state, owing to the secondary intermolecular interactions between EC and 5-FU. The ex vivo adhesion experiments suggested that the JCS fibers could stick firmly to the intestine membranes. In vitro dissolution tests showed the JCS fibers released only 7.8% ± 3.5% of the loaded 5-FU in an acid condition. In vivo gavage administration verified that the JCS fibers effectively promoted the absorbance of 5-FU in a synergistic manner, better than the double-layer core–shell and Janus nanofibers, and near fourfold than the drug solutions as a control. The present protocol opens a new way for developing novel multifunctional nanomaterials with the JCS nanostructure as a powerful supporting platform.

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Acknowledgements

Mr. Yingfu Bai’s precious help on the investigations are highly appreciated.

Funding

Shanghai Natural Science Foundation (nos. 21ZR1459500 and 20ZR1439000), the Municipal Commission of Health and Family Planning Foundation of Shanghai (no. 202140413), the Medical Health Science and Technology Innovation Plan of Jinan (nos. 202019202 and 202134037), the Science and technology innovation project of Medical staff in Shandong Province, the Natural Science Foundation of Shandong Province (nos. ZR2020QH264 and ZR2021MH129), the Science and Technology Development Fund of Macao Special Administrative Region (0061/2023/RIA1), and the Macao Polytechnic University Research Fund (RP/FCSD-01/2023).

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Author notes

  1. Jianfeng Zhou and Tao Yi contributed equally to this work.

Authors and Affiliations

  1. School of Materials & Chemistry, University of Shanghai for Science and Technology, Shanghai, 200093, China

    Jianfeng Zhou, Zhiyuan Zhang & Deng-Guang Yu

  2. Faculty of Health Sciences and Sports, Macao Polytechnic University, Macau, 999078, China

    Tao Yi

  3. The Base of Achievement Transformation, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, 200433, China

    Ping Liu

  4. Department of Dermatology, Naval Medical Center, Naval Medical University, Shanghai, 200052, China

    Liangzhe Wang & Yuanjie Zhu

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  1. Jianfeng Zhou
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  4. Deng-Guang Yu
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  5. Ping Liu
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Jianfeng Zhou, Tao Yi, Zhiyuan Zhang and Liangzhe Wang. The first draft of the manuscript was written by Jianfeng Zhou and Tao Yi, and all authors commented on the previous versions of the manuscript. Jianfeng Zhou, Tao Yi, and Zhiyuan Zhang contributed to the data curation and the preparation of figures. Tao Yi, Deng-Guang Yu, and Ping Liu acquired the funding. Ping Liu, Liangzhe Wang, and Yuanjie Zhu edited and proofread the manuscript. All authors read and approved the final version of the manuscript.

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Correspondence to Deng-Guang Yu, Ping Liu or Yuanjie Zhu.

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Zhou, J., Yi, T., Zhang, Z. et al. Electrospun Janus core (ethyl cellulose//polyethylene oxide) @ shell (hydroxypropyl methyl cellulose acetate succinate) hybrids for an enhanced colon-targeted prolonged drug absorbance. Adv Compos Hybrid Mater 6, 189 (2023). https://doi.org/10.1007/s42114-023-00766-6

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