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Fe3O4@PVP@DOX magnetic vortex hybrid nanostructures with magnetic-responsive heating and controlled drug delivery functions for precise medicine of cancers

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Abstract

Precise magnetic hyperthermia/chemo synergistic therapy has attracted great attention as a promising cancer therapy. However, how to improve the hyperthermia efficiency and precisely control the drug release in vivo are still challenging issues associated with the clinical precision medicine of cancers. To solve these problems, magnetic vortex Fe3O4@PVP@DOX nanostructures with magneto-triggered on-demand hyperthermia, magnetic responsive controllable drug delivery functions, and MRI T2-weighted signal enhancement were successfully developed for the hyperthermia and chemotherapy synergetic theranostic of cancers. This strategy utilizes the advantage of magnetic field stimulus which can be on-demand applied to any organ without taking account of the depth. In vitro experiments reveal the excellent on-demand heating efficiency, magnetic-responsive drug release, high MRI T2 signals and low cytotoxicity. More importantly, the results of in vivo animal experiments show that the magnetic vortex nanoplatform can effectively perform magnetic response on-demand heat therapy, and DOX drug release in the presence of a magnetic field, leading to an efficient synergistic effect in inhibiting tumor growth without any side effect. Therefore, these magnetic-responsive magnetic vortex nanostructures provide us a new strategy for the development of next-generation stimuli-responsive multifunctional theranostic platform for the clinical precision medicine of cancers.

Graphical abstract

The multifunctional nanoplatform with an excellent heating efficiency was successfully developed for synergetic theranostic with enhanced MRI contrast.

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Funding

This project has been assisted by the program of Shanghai Technology Research Leader (18XD1423800), the National Natural Science Foundation of China (Grant No 51671146, 51971162, U1933112), the Fundamental Research Funds for the Central Universities, Shanghai Collaborative Innovation Program on Regenerative Medicine and Stem Cell Research (2019CXJQ01), and the “Crossover” Research Fund of the Ninth People's Hospital of Shanghai Jiao Tong University (No. JYJC202102).

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  1. Xiao Wang, Yiyao Qi and Zhenrong Hu these authors contributed equally.

Authors and Affiliations

  1. Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200123, People’s Republic of China

    Xiao Wang, Yiyao Qi, Lijun Jiang, Wenwen Jia & Wei Lu

  2. Shanghai Key Lab of D&A for Metal Functional Materials, School of Materials Science and Engineering, Tongji University, Shanghai, 201804, People’s Republic of China

    Xiao Wang, Fei Pan, Zhen Xiang & Wei Lu

  3. Department of Oral & Maxillofacial-Head & Neck Oncology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China

    Zhenrong Hu & Jingzhou Hu

  4. Department of Urology, Huashan Hospital, Fudan University, Shanghai, 200032, China

    Zuquan Xiong

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  1. Xiao Wang
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Wang, X., Qi, Y., Hu, Z. et al. Fe3O4@PVP@DOX magnetic vortex hybrid nanostructures with magnetic-responsive heating and controlled drug delivery functions for precise medicine of cancers. Adv Compos Hybrid Mater 5, 1786–1798 (2022). https://doi.org/10.1007/s42114-022-00433-2

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