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Antimicrobial curcumin nanoparticles downregulate joint inflammation and improve osteoarthritis

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Abstract

Osteoarthritis (OA) is characterized by degenerative lesions in articular cartilage and becomes increasingly difficult to treat as the inflammatory response progresses and damage to joint cartilage occurs. Therefore, novel therapeutic options are required. In this study, curcumin (Cur) nanoparticles (Cur@Zn&TA) were prepared using a metal–phenol network based on Zn2+ ions and tannic acid (TA). The poor bioavailability of Cur, caused by low and rapid metabolism, was resolved by metal–phenol network wrapping, thus prolonging the time of action of the drug. This composite nanostructure has several biological effects, including anti-inflammatory, antibacterial, and chondroprotective, which are ideal for treating OA. Animal tests indicated that Cur@Zn&TA nanoparticles can be directly injected into the joint cavity to regulate the inflammatory response of OA, effectively promoting OA repair and preventing bacterial infections to achieve rapid and long-term treatment of OA.

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Antimicrobial curcumin nanoparticles were developed to improve osteoarthritis.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

This work was supported by grant from Zhejiang Provincial Natural Science Foundation of China (No. LGF19H180007).

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Authors and Affiliations

  1. The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325200, China

    Zhengqiu Lin, Shicui Jiang, Xiuzhi Ye, Minghai Dai, Guojing Yang & Liangle Liu

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  1. Zhengqiu Lin
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  2. Shicui Jiang
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  3. Xiuzhi Ye
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  4. Minghai Dai
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  5. Guojing Yang
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  6. Liangle Liu
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Correspondence to Guojing Yang or Liangle Liu.

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Lin, Z., Jiang, S., Ye, X. et al. Antimicrobial curcumin nanoparticles downregulate joint inflammation and improve osteoarthritis. Macromol. Res. 31, 1179–1187 (2023). https://doi.org/10.1007/s13233-023-00196-9

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  • DOI: https://doi.org/10.1007/s13233-023-00196-9

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