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Multifunctional electroactive bio-adhesive for robustly-integrated wound therapy and postoperative wound-status warning and assessment

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Abstract

Wound abnormalities such as secondary wound laceration and inflammation are common postoperative health hazards during clinical procedures. The continuous treatment, healing induction, and real-time visualization of wound status and complications, including wound re-tearing, inflammation, and morphology, are key focal points for comprehensive healthcare. Herein, an on-demand quadruple energy dissipative strategy was proposed for the nanoengineering of a physically and chemically synergistic double-layer gelatin-based bio-adhesive (DLGel) by combining a multi-network adhesive layer and a versatile electroactive energy dissipative layer based on contrivable interlocking micro-pillar arrays and crosslinked polymer chains. The subtly multiple energy dissipation designs enable DLGel with robust adhesive strength to omnipotently wet and dynamic tissue, providing a basis for reliable wound closure. DLGel achieves comprehensive wound-healing induction through electrical stimulation and possesses reversible underwater light/thermal adhesion, excellent hemostatic performance, outstanding antimicrobial properties, and self-repair capability. Furthermore, a novel deep-learning strategy is creatively established to respond to mechanical deformation due to wound anomalies. This strategy translates biological information into visual graphics, providing real-time early warning and assessment of postoperative wound-abnormality/-morphology, such as laceration, inflammation, and necrosis. Therefore, DLGel and its associated signal collection and processing protocol enable the integration of reliable wound closure, wound healing, and real-time postoperative wound-status warning and assessment within the unobservable and undetectable “black box” regions in a context of non-clinical comprehensive therapy.

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Acknowledgments

This work was financially supported by Fellowship of China Postdoctoral Science Foundation (No. 2023M732159), the National Natural Science Foundation of China (Nos. 22308209 and 2207081675), Key R&D Program of Shaanxi Province (No. 2022GY-272), and Young Talent Support Program Project of Shaanxi University Science and Technology Association (No. 20200424).

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  1. Ouyang Yue, Xuechuan Wang, and Mengdi Hou contributed equally to this work.

Authors and Affiliations

  1. College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & Technology, Xi’an, 710021, China

    Ouyang Yue, Xuechuan Wang, Manhui Zheng, Xiaoliang Zou, Zhongxue Bai & Xinhua Liu

  2. College of Pharmacy, Shaanxi University of Chinese Medicine, Xi’an, 710021, China

    Mengdi Hou

  3. Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, 710021, China

    Siwei Sun

  4. School of Mechanical Engineering, Chengdu University, Chengdu, 610000, China

    Chunlin Liu

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  1. Ouyang Yue
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Correspondence to Xuechuan Wang or Xinhua Liu.

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Multifunctional electroactive bio-adhesive for robustly-integrated wound therapy and postoperative wound-status warning and assessment

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Yue, O., Wang, X., Hou, M. et al. Multifunctional electroactive bio-adhesive for robustly-integrated wound therapy and postoperative wound-status warning and assessment. Nano Res. 17, 4359–4370 (2024). https://doi.org/10.1007/s12274-023-6384-5

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