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Single-walled carbon nanotube based SERS substrate with single molecule sensitivity

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Abstract

In single molecule study, surface-enhanced Raman scattering (SERS) has the advantage of specifically providing structural information of the molecules targeted. The main challenge in single molecule SERS is developing reusable plasmonic substrates that ensures single molecule sensitivity and acquires intrinsic information of molecules. Here, we proposed a strategy to utilize single-walled carbon nanotubes (SWNTs) to construct SERS substrates. Employing ultrasonic spray pyrolysis, we prepared in situ polyhedral gold nanocrystals closely spaced and attached to nanotubes, ensuring valid hot spots formed along the tube-walls. With such SERS substrates, we proved the single molecule detection by the statistical analysis based on the natural abundance of isotopes. Since SWNTs provide non-chemical bonding adsorption sites, our SERS substrates are easily reusable and have a unique advantage of preserving the intrinsic property of the molecules detected. Using SWNTs to build SERS substrates may become a powerful general strategy in various static and dynamic studies of single molecules.

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Acknowledgements

This research is financially supported by the National key R&D Program of China (No. 2016YFA0201904), the National Natural Science Foundation of China (Nos. 21873008 and 21631002), Beijing National Laboratory for Molecular Sciences (No. BNLMS-CXTD-202001) and Shenzhen Basic Research Project (No. JCYJ20170817113121505).

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  1. Beijing National Laboratory for Molecular Sciences, Key Laboratory for the Physics and Chemistry of Nanodevices, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China

    Chenmaya Xia, Daqi Zhang, Henan Li, Sheng Li, Haoming Liu, Li Ding, Xiyan Liu, Min Lyu, Ruoming Li, Juan Yang & Yan Li

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  1. Chenmaya Xia
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  2. Daqi Zhang
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Correspondence to Juan Yang or Yan Li.

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Xia, C., Zhang, D., Li, H. et al. Single-walled carbon nanotube based SERS substrate with single molecule sensitivity. Nano Res. 15, 694–700 (2022). https://doi.org/10.1007/s12274-021-3549-y

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