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The crucial role of LncRNA MIR210HG involved in the regulation of human cancer and other disease

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Abstract

Long noncoding RNAs (lncRNAs) have evoked considerable interest in recent years due to their critical functions in the regulation of disease processes. Abnormal expression of lncRNAs is found in multiple diseases, and lncRNAs have been exploited for diverse medical applications. The lncRNA MIR210HG is a recently discovered lncRNA that is widely dysregulated in human disease. MIR210HG was described to have biological functions with potential roles in disease development, including cell proliferation, invasion, migration, and energy metabolism. And MIR210HG dysregulation was confirmed to have promising clinical values in disease diagnosis, treatment, and prognosis. In this review, we systematically summarize the expression profiles, roles, underlying mechanisms, and clinical applications of MIR210HG in human disease.

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Funding

This work was supported by the National Key Research and Development Program of China (2019YFC0840600 and 2019YFC0840609), Young Scientists Fund of the National Natural Scientific Foundation (NSFC81900572), and the Independent Project Fund of the State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the National Key Research and Development Program of China (2022zz10).

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  1. Juan Lu and Danhua Zhu contributed equally to this work.

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  1. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Shangcheng District, No. 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China

    Juan Lu, Danhua Zhu, Xiaoqian Zhang, Jie Wang, Hongcui Cao & Lanjuan Li

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Lanjuan Li and Hongcui Cao designed and guided the study. Juan Lu and Danhua Zhu wrote and edited the manuscript. Xiaoqian Zhang and Jie Wang helped with the reference collection. All authors read and approved the final manuscript.

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Lu, J., Zhu, D., Zhang, X. et al. The crucial role of LncRNA MIR210HG involved in the regulation of human cancer and other disease. Clin Transl Oncol 25, 137–150 (2023). https://doi.org/10.1007/s12094-022-02943-3

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