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miRNA Biogenesis and Regulation of Diseases: An Updated Overview

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MicroRNA Profiling

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2595))

Abstract

MicroRNAs (miRNAs) are small RNA molecules, with their role in gene silencing and translational repression by binding to the target mRNAs. Since it was discovered in 1993, miRNA is found in all eukaryotic cells conserved across the species. miRNA-size molecules are also known to be found in prokaryotes. Regulation of miRNAs is extensively studied for their role in biological processes as well as in development and progression of various human diseases including neurodegenerative diseases, cardiovascular disease, and cancer. miRNA-based therapy has a promising application, and with a good delivery system, miRNA therapeutics can potentially be a success. miRNAs and EVs have potential therapeutic and prognostic application in a range of disease models. This chapter summarizes miRNA biogenesis and explores their potential roles in a variety of diseases. miRNAs hold huge potential for diagnostic and prognostic biomarkers and as predictors of drug response.

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Authors and Affiliations

  1. Department of Biophysics, University of Delhi, New Delhi, India

    Anchal Vishnoi

  2. Department of Science, South East Technological University, Waterford, Ireland

    Sweta Rani

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  1. Anchal Vishnoi
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  2. Sweta Rani
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Correspondence to Sweta Rani .

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  1. Department of Science, South East Technological University, Waterford, Ireland

    Sweta Rani

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Vishnoi, A., Rani, S. (2023). miRNA Biogenesis and Regulation of Diseases: An Updated Overview. In: Rani, S. (eds) MicroRNA Profiling. Methods in Molecular Biology, vol 2595. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2823-2_1

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  • DOI: https://doi.org/10.1007/978-1-0716-2823-2_1

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