Abstract
Mesenchymal stem cells (MSCs) have become popular tool cells in the field of transformation and regenerative medicine due to their function of cell rescue and cell replacement. The dynamically changing mitochondria serve as an energy metabolism factory and signal transduction platform, adapting to different cell states and maintaining normal cell activities. Therefore, a clear understanding of the regulatory mechanism of mitochondria in MSCs is profit for more efficient clinical transformation of stem cells. This review highlights the cutting-edge knowledge regarding mitochondrial biology from the following aspects: mitochondrial morphological dynamics, energy metabolism and signal transduction. The manuscript mainly focuses on mitochondrial mechanistic insights in the whole life course of MSCs, as well as the potential roles played by mitochondria in MSCs treatment of transplantation, for seeking pivotal targets of stem cell fate regulation and stem cell therapy.
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References
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This work was supported by the National Key Technology Research and Development Program of China (2022YFC2704400, 2022YFC2704403 and 2022YFC2702504); the National Clinical Research Center of Obstetrics and Gynecology (2015BAI13B05) and National Natural Science Foundation of China (82101700).
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Yang Liu Conceptualized and wrote the original draft. Lingjuan Wang edited the manuscript. Jihui Ai and Kezhen Li administrated and supervised the project. All authors read and approved the final manuscript.
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Liu, Y., Wang, L., Ai, J. et al. Mitochondria in Mesenchymal Stem Cells: Key to Fate Determination and Therapeutic Potential. Stem Cell Rev and Rep 20, 617–636 (2024). https://doi.org/10.1007/s12015-024-10681-y
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DOI: https://doi.org/10.1007/s12015-024-10681-y