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The Roles and Mechanisms of TRAT1 in the Progression of Non-Small Cell Lung Cancer

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Abstract

Objective

T cell receptor-associated transmembrane adaptor 1 (TRAT1) is one of the hub genes regulating T cell receptors (TCRs). Herein, the roles of TRAT1 in the prognosis and immune microenvironment of non-small cell lung cancer (NSCLC) were investigated.

Methods

The expression and prognosis values of TRAT1 in NSCLC, and the relationship between TRAT1 expression levels and cancer immune cell infiltration was identified via the TIMER, UALCAN, TISIDB, and other databases. The mechanism of TRAT1 in NSCLC was analyzed using gene set enrichment analysis (GSEA).

Results

The expression level of TRAT1 was decreased in NSCLC tissues. Low TRAT1 expression was associated with shorter overall survival of patients with NSCLC and was related to gender, smoking, and tumor grade. TRAT1 was involved in regulating immune response, TCR signaling pathway, PI3K/AKT, and other processes. TRAT1 expression levels were positively correlated with immune cell infiltration in NSCLC.

Conclusion

Down-regulation of TRAT1 expression was associated with an unfavorable prognosis and immune infiltration of NSCLC.

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Author notes

  1. The authors contributed equally to this work.

Authors and Affiliations

  1. Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Qiang Guo, Si-hua Wang, Song Tong & Chuang-yan Wu

  2. Department of Neurocritical Care Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, China

    Yan-mei Ji

  3. Department of Oncology, Huanggang Central Hospital Affiliated to Yangtze University, Huanggang, 438000, China

    Dan Li

  4. Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China

    Xiang-chao Ding

Authors
  1. Qiang Guo
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  2. Si-hua Wang
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  3. Yan-mei Ji
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  4. Song Tong
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  5. Dan Li
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  6. Xiang-chao Ding
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Corresponding author

Correspondence to Chuang-yan Wu.

Ethics declarations

The authors declare no conflicts of interest.

Author Si-hua WANG is a member of the Young Editorial Board for Current Medical Science. The paper was handled by other editors and has undergone rigorous peer review process. Author Si-hua WANG was not involved in the journal’s review of, or decision related to, this manuscript.

Additional information

This study was supported by grants from the Natural Science Foundation of Hubei (No. 2020CFB392), and the National Natural Science Foundation of China (No. 82100115, No. 82100116 and No. 82070431).

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Guo, Q., Wang, Sh., Ji, Ym. et al. The Roles and Mechanisms of TRAT1 in the Progression of Non-Small Cell Lung Cancer. CURR MED SCI 42, 1186–1200 (2022). https://doi.org/10.1007/s11596-022-2625-1

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  • DOI: https://doi.org/10.1007/s11596-022-2625-1

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