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Voltammetric studies on the interaction of epinephrine with DNA base on a glassy carbon electrode modified with Au nanoparticles

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Abstract

The interaction of epinephrine (EP) with DNA, including double-strand DNA (dsDNA) and single-strand DNA (ssDNA) were investigated both in Mcllvaine buffer solution and on a glassy carbon electrode (GCE) modified with Au nanoparticles (nanoAu/GCE). In pH 7.0 Mcllvaine buffer solution, EP had a sensitive oxidation current peak at 0.162 V (vs. SCE) on the nanoAu/GCE. Factors influencing the interaction in Mcllvaine buffer solution were optimized, and some electrochemical parameters, such as number of electron transferred, the standard rate constant of the electrode reaction (K s) were compared in the presence and absence of DNA. The binding ratio (m) of EP with DNA and the equilibrium constant (β) were also calculated. EP did not interact with DNA via intercalation mode.

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Acknowledgments

The work was supported by the National Natural Science Foundation of China (No. 21105023) and the Natural Science Foundation Committee of Shandong Province, China (No. BS2013HZ027 and ZR2009BM003).

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Authors and Affiliations

  1. Department of Chemistry and Chemical Engineering, Heze University, Heze, 274015, Shandong, China

    Xueliang Wang & Zhangyu Yu

  2. School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, 273165, Shandong, China

    Jinjin Li, Tao Wang & Zhangyu Yu

Authors
  1. Xueliang Wang
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  2. Jinjin Li
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  3. Tao Wang
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  4. Zhangyu Yu
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Correspondence to Xueliang Wang or Zhangyu Yu.

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Wang, X., Li, J., Wang, T. et al. Voltammetric studies on the interaction of epinephrine with DNA base on a glassy carbon electrode modified with Au nanoparticles. Ionics 21, 1105–1110 (2015). https://doi.org/10.1007/s11581-014-1243-8

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  • DOI: https://doi.org/10.1007/s11581-014-1243-8

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