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Ultrasound-induced biophysical effects in controlled drug delivery

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Abstract

Ultrasound is widely used in biomedical engineering and has applications in conventional diagnosis and drug delivery. Recent advances in ultrasound-induced drug delivery have been summarized previously in several reviews that have primarily focused on the fabrication of drug delivery carriers. This review discusses the mechanisms underlying ultrasound-induced drug delivery and factors affecting delivery efficiency, including the characteristics of drug delivery carriers and ultrasound parameters. Firstly, biophysical effects induced by ultrasound, namely thermal effects, cavitation effects, and acoustic radiation forces, are illustrated. Secondly, the use of these biophysical effects to enhance drug delivery by affecting drug carriers and corresponding tissues is clarified in detail. Thirdly, recent advances in ultrasound-triggered drug delivery are detailed. Safety issues and optimization strategies to improve therapeutic outcomes and reduce side effects are summarized. Finally, current progress and future directions are discussed.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (31971169, 81822022, 81771846, 81571810), the Beijing Natural Science Foundation (7182180), National Key Research and Development Program of China (2018YFC0116003, 2016YFA0201400), Beijing Talents Foundation (2018000021223ZK48), and Peking University Third Hospital (BYSYZD2019018, jyzc2018-02, BYSY2015023).

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  1. Department of Ultrasound, Peking University Third Hospital, Beijing, 100191, China

    Lulu Zhang, Zhuohua Lin, Lan Zeng, Fan Zhang, Lihong Sun, Suhui Sun, Ping Wang, Menghong Xu, Jinxia Zhang, Xiaolong Liang & Huiyu Ge

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  1. Lulu Zhang
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Zhang, L., Lin, Z., Zeng, L. et al. Ultrasound-induced biophysical effects in controlled drug delivery. Sci. China Life Sci. 65, 896–908 (2022). https://doi.org/10.1007/s11427-021-1971-x

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