Abstract
The reduction of carboxamides into high value-added amines is a very interesting but great challenging topic. Herein we demonstrate that polynuclear lanthanide-oxo clusters Ln16 (Ln = Eu and Gd) can be used as efficient catalyst to reduce primary and secondary carboxamides to amines with excellent yield of 71%–98% and broad substrates scope. The methodology can extend to the gram-scale synthesis of phenethylamine drug with 93% yield. Based on the isolation and characterization of catalytic intermediates, a catalytic mechanism involving multipath reaction is proposed. This work provides efficient lanthanide cluster catalysts for the reduction of carboxamides to amines.
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This work was supported by the National Natural Science Foundation of China (92161104, 21871224, 92161203, 21721001).
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Weng, ZZ., Chen, CL., Ye, LW. et al. Lanthanide-oxo clusters for efficient catalytic reduction of carboxamides. Sci. China Chem. 66, 443–448 (2023). https://doi.org/10.1007/s11426-022-1493-y
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DOI: https://doi.org/10.1007/s11426-022-1493-y