Aflatoxin detection technologies: recent advances and future prospects

Liu, Shenqi; Jiang, Shanxue; Yao, Zhiliang; Liu, Minhua

doi:10.1007/s11356-023-28110-x

Aflatoxin detection technologies: recent advances and future prospects

Review Article
Published: 16 June 2023

Volume 30, pages 79627–79653, (2023)
Cite this article

Environmental Science and Pollution Research Aims and scope Submit manuscript

Shenqi Liu^1,2,
Shanxue Jiang^1,2,
Zhiliang Yao ORCID: orcid.org/0000-0001-5125-8245^1,2 &
…
Minhua Liu^1,2

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Abstract

Aflatoxins have posed serious threat to food safety and human health. Therefore, it is important to detect aflatoxins in samples rapidly and accurately. In this review, various technologies to detect aflatoxins in food are discussed, including conventional ones such as thin-layer chromatography (TLC), high performance liquid chromatography (HPLC), enzyme linked immunosorbent assay (ELISA), colloidal gold immunochromatographic assay (GICA), radioimmunoassay (RIA), fluorescence spectroscopy (FS), as well as emerging ones (e.g., biosensors, molecular imprinting technology, surface plasmon resonance). Critical challenges of these technologies include high cost, complex processing procedures and long processing time, low stability, low repeatability, low accuracy, poor portability, and so on. Critical discussion is provided on the trade-off relationship between detection speed and detection accuracy, as well as the application scenario and sustainability of different technologies. Especially, the prospect of combining different technologies is discussed. Future research is necessary to develop more convenient, more accurate, faster, and cost-effective technologies to detect aflatoxins.

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pH and Titratable Acidity

Enzyme-Linked Immunosorbent Assay (ELISA)

Application of nanotechnology in different aspects of the food industry

Article Open access 22 March 2022

Data availability

All data generated or analysed during this study are included in this published article.

Abbreviations

ADC:: Analogue-digital-converter
AFB₁ :: Aflatoxin B1
AFB₂ :: Aflatoxin B2
AFG₁ :: Aflatoxin G1
AFG₂ :: Aflatoxin G2
AFM₁ :: Aflatoxin M1
AFM₂ :: Aflatoxin M2
AFP₁ :: Aflatoxin P1
AFQ₁ :: Aflatoxin Q1
AuNPs:: Gold nanoparticles
AuNRs:: Gold nanorods
BSA:: Bovine albumin
CM:: Chemical enhancement
CMO:: Carboxymethoxylamine hemihydrochloride
CTAB:: Cetyltrimethylammonium bromide
dcFLISA:: Direct competitive fluorescence-linked immunosorbent assay
ELISA:: Enzyme linked immunosorbent assay
EM:: Electromagnetic enhancement
FA:: Fluorescence anisotropy
FLD:: Fluorescence detector
FS:: Fluorescence spectroscopy
GICA:: Colloidal gold immunochromatographic assay
HLB:: Hydrophilic-lipophilic balance
HPLC:: High performance liquid chromatography
ICA:: Immunochromatographic assay
KLH:: Keyhole limpet
LED:: Light emitting diode
LFIA:: Lateral flow immunoassay
LLE:: Liquid-liquid extraction
LOD:: Limit of detection
LTP:: Low temperature partitioning
MIPs:: Molecularly imprinted polymers
MIT:: Molecular imprinting technology
MRLs:: Maximum residue levels
MOF:: Metal-organic framework
MOFLISA:: MOF-linked immunosorbent assay
OA:: Operational amplifier integrated circuit
OVA:: Ovalbumin
PBS:: Phosphate-buffered saline
PBST:: Phosphate-buffered saline with Tween 20
PRiME:: Process, robustness, improvements, matrix effects, ease of use
QCM:: Quartz crystal microbalance
QDs:: Quantum dots
RIA:: Radioimmunoassay
RSD:: Relative standard deviation
SERS:: Surface-enhanced Raman scattering
SPR:: Surface plasmon resonance
TFA:: Trifluoroacetic acid
TLC:: Thin-layer chromatography
TMB:: Tetramethylbenzidine
TMR:: Tetramethylrhodamine
UHPLC-MS/MS:: Ultra-high performance liquid chromatography-tandem mass spectrometry

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This work was supported by the Beijing Municipal Commission of Education (grant no. PXM2019_014213_000007) and School Level Cultivation Fund of Beijing Technology and Business University for Distinguished and Excellent Young Scholars (grant no. BTBUYP2020).

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School of Ecology and Environment, Beijing Technology and Business University, Beijing, 100048, China
Shenqi Liu, Shanxue Jiang, Zhiliang Yao & Minhua Liu
State Environmental Protection Key Laboratory of Food Chain Pollution Control, Beijing Technology and Business University, Beijing, 100048, China
Shenqi Liu, Shanxue Jiang, Zhiliang Yao & Minhua Liu

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Shenqi Liu
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Shanxue Jiang
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Zhiliang Yao
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Minhua Liu
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Shenqi Liu: Methodology, Investigation, Writing - Original Draft; Shanxue Jiang: Conceptualization, Methodology, Writing - Original Draft, Writing - Reviewing and Editing; Zhiliang Yao: Supervision, Funding acquisition, Writing - Reviewing and Editing; Minhua Liu: Supervision, Writing - Reviewing and Editing

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Liu, S., Jiang, S., Yao, Z. et al. Aflatoxin detection technologies: recent advances and future prospects. Environ Sci Pollut Res 30, 79627–79653 (2023). https://doi.org/10.1007/s11356-023-28110-x

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Received: 25 November 2022
Accepted: 01 June 2023
Published: 16 June 2023
Issue Date: July 2023
DOI: https://doi.org/10.1007/s11356-023-28110-x

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Aflatoxin detection technologies: recent advances and future prospects