Abstract
A green and eco-friendly route for the almost quantitative BOC protection of a large variety of aliphatic and aromatic amines, amino acids, and amino alcohols is reported in catalyst and solvent-free media under mild reaction conditions. The products were confirmed by 1H, 13C NMR, IR spectroscopy, and in some cases, elemental analysis. This protocol does not require any water quenches, solvent separations, and purification steps, such as recrystallization and column chromatography.
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Acknowledgments
Dr. B. Viswanadham thanks the University of KwaZulu-Natal for the award of an AES Postdoctoral Fellow.
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Viswanadham, B., Mahomed, A.S., Friedrich, H.B. et al. Efficient and expeditious chemoselective BOC protection of amines in catalyst and solvent-free media. Res Chem Intermed 43, 1355–1363 (2017). https://doi.org/10.1007/s11164-016-2702-9
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DOI: https://doi.org/10.1007/s11164-016-2702-9