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N-Boc Protection of Amines Using Silica Propyl(N-methyl) Imidazolium Chloride as an Efficient and Reusable Catalyst

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Abstract

A simple and efficient method for the N-Boc protection of amines using (Boc)2O in the presence of a catalytic amount of silica propyl(N-methyl) imidazolium chloride ([Sipmim]Cl) is introduced. The catalyst was efficient and reusable for this process under solvent-free conditions at ambient temperature. This methodology has several advantages in comparison with currently used methods including high yields, simple workup procedure, short reaction time, and clean and mild reaction conditions.

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Acknowledgments

The authors thank the Research Committee of Persian Gulf University for financial support of this work.

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Authors and Affiliations

  1. Department of Chemistry, Persian Gulf University, 75169, Bushehr, Iran

    Somaye Karimian

  2. Young Researchers and Elite Club, Bushehr Branch, Islamic Azad University, Bushehr, Iran

    Somaye Karimian & Hassan Tajik

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  1. Somaye Karimian
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  2. Hassan Tajik
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Correspondence to Somaye Karimian.

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Karimian, S., Tajik, H. N-Boc Protection of Amines Using Silica Propyl(N-methyl) Imidazolium Chloride as an Efficient and Reusable Catalyst. Iran J Sci Technol Trans Sci 40, 267–274 (2016). https://doi.org/10.1007/s40995-016-0091-y

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  • DOI: https://doi.org/10.1007/s40995-016-0091-y

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