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Chemical Composition of Alpinia oxyphylla Miq. and Chrysin Protective Activity on Neuron Cells

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Pharmaceutical Chemistry Journal Aims and scope

At present, the global population is aging severely and neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases have a very serious impact on human society and patients. The plant of Alpinia oxyphylla Miq. is a Traditional Chinese Medicine commonly used to treat vomiting, which has been found in recent years to produce neuroprotective effects. In this study, chemical consitituents of the ethyl acetate extract fraction of the dried fruits of A. oxyphylla was analyzed and 15 compounds were isolated, three of which were identified for the first time. The neuroprotective effect of chrysin was verified by glutamate-induced PC12 cells.

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References

  1. P. Chen, P. Wang, Z. Jiao, and L. Xiang, Helv. Chim. Acta, 97, 388 – 397 (2014).

    Article  CAS  Google Scholar 

  2. K. Mao and G. Zhang, FEBS J., 15716 (2021).

  3. G. Abate, M. Marziano, W. Rungratanawanich, et al., Oxid. Med. Cell. Longev., 2017, 7039816 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Y.Wang, M.Wang, K. Fan, et al., J. Ethnopharmacol, 217, 98 – 106 (2018).

    Article  CAS  PubMed  Google Scholar 

  5. Z. Meng, H. Chen, and S. Meng, Neurotox. Res., 39, 1665 – 1677 (2021).

    Article  PubMed  Google Scholar 

  6. Y. Chang, C. Tsai, C. Wang, et al., Biosci. Biotechnol. Biochem, 77, 229 – 234 (2013).

    Article  CAS  PubMed  Google Scholar 

  7. S. Wang, Y. Zhao, J. Zhang, et al., J. Ethnopharmacol, 168, 182 – 190 (2015).

    Article  PubMed  Google Scholar 

  8. Y. Li, F. Chen, J. Wang, et al., Chem. Cent. J., 7, 134 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. S. Shi, X. Zhao, B. Liu, et al., Oxid. Med. Cell. Longev., e451802 (2014).

  10. M. Zhao, Q. Du, L. Zuo, et al., Clin. Chin. Mater. Medica., 37, 230 – 235 (2021).

    Google Scholar 

  11. R. Tan, Q. Zhao, Q. Lu, et al., World Sci. Technol. Tradit. Chin. Med. Mater. Medica, 21, 565 – 572 (2019).

    Google Scholar 

  12. Z. Lou, J. Wang, and G. Zhang, China J. Tradit. Chin. Med. Pharm., 33, 1004 – 1007 (2018).

    CAS  Google Scholar 

  13. S. Wang, J. Zhong, Q. Zhang, et al, Carbohydr. Polym., 229, 115405 (2020).

    Article  Google Scholar 

  14. J. Sui, F. Li, Y. Guo, et al, Drug Eval. Res., 43, 2120 – 2126 (2020).

    Google Scholar 

  15. M. Lai, S. Hsiu, S. Tsai, et al., J. Pharm. Pharmacol. 55, 205 – 209 (2003).

    Article  CAS  PubMed  Google Scholar 

  16. H. Park, S. Yoon, J. Choi, et al., Eur. J. Pharmacol, 574, 112 – 119 (2007).

    Article  CAS  PubMed  Google Scholar 

  17. G. Chen, H. Xu, Y. Wu, et al., Phytomedicine, 92, 153719 (2021).

    Article  CAS  PubMed  Google Scholar 

  18. H. Kikuzaki, S. Tesaki, S. Yonemori, et al., Phytochemistry, 56, 109 – 114 (2001).

    Article  CAS  PubMed  Google Scholar 

  19. D. Peng, L. Bai, X. Chen, et al., Chem. Res. Appl., 31, 507 – 510 (2019).

    Google Scholar 

  20. E. Kulmagambetova, A. Seitembetova, A. Kulyjasov, et al., Russ. Chem. Bull., 52, 752 – 754 (2003).

    Article  CAS  Google Scholar 

  21. S. Peng, L. Han, E. Liu, et al., Chin. J. Magn. Reson., 30, 140 – 147 (2013).

    CAS  Google Scholar 

  22. I. Kuzovkina, A. Guseva, D. Kovács, et al., Russ. J. Plant Physiol., 52, 77 – 82 (2005).

    Article  CAS  Google Scholar 

  23. Z. Li, X. Cao, X.Wang, et al., Org. Prep. Proced. Int., 41, 327 – 330 (2009).

  24. Y. Sawai, J. Moon, K. Sakata, et al., J. Agric. Food Chem., 53, 3598 – 3604 (2005).

    Article  CAS  PubMed  Google Scholar 

  25. Y. Nishiyama, Y. Makino, S. Hamanaka, et al., Bull. Chem. Soc. Jpn., 62, 1682 – 1684 (1989).

    Article  CAS  Google Scholar 

  26. S. Wang, Dissertation, Guiyang (2007).

  27. S. Singh, Y. Kumar, S. Kumar, et al, Indian J. Pharm. Sci., 71, 328 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Y. Pan, L. Zhang, and G. Chen, Analyst, 126, 1519 – 1523 (2001).

    Article  CAS  PubMed  Google Scholar 

  29. S. Sang, K. Lapsley, W. Jeong, et al., J. Agric. Food Chem., 50, 2459 – 2463 (2002).

    Article  CAS  PubMed  Google Scholar 

  30. B. Fraga, M. Hernández, T. Mestres, et al., Phytochemistry, 39, 617 – 619 (1995).

    Article  CAS  Google Scholar 

  31. M. Sholichin, K. Yamasaki, R. Kasai, et al., Chem. Pharm. Bull. (Tokyo), 28, 1006 – 1008 (1980).

    Article  CAS  Google Scholar 

  32. N. Kamal, C. Clements, A. Gray, et al., J. Pharm. Sci-Us., (2018).

  33. R. Mani and V. Natesan, Phytochemistry, 145, 187 – 196 (2018).

    Article  CAS  PubMed  Google Scholar 

  34. L. Su and Y. Fan, J. Tradit. Chin. Med. Pharm., 27, 113 – 118 (2021).

    Google Scholar 

  35. Z. Zheng, C. Cheung, H. Lyu, et al., J. Clin. Neurosci., 64, 242 – 251 (2019).

    Article  CAS  PubMed  Google Scholar 

  36. Y. Taheri, H. Suleria, N. Martins, et al., BMC Complement. Med. Ther., 20, 241 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. D. Huynh, T. Ngau, N. Nguyen, et al., Mol. Biol. Rep., 47, 9779 – 9789 (2020).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, P. R. China

    Shuyu Xu, Xiaoyun Ji, Zheng Shi, Rui Tan & Hezhong Jiang

  2. Department of Laboratory Medicine, The Third People’s Hospital of Chengdu/Affiliated Hospital of Southwest Jiaotong University, Chengdu, 610014, P. R. China

    Xin Chen

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  1. Shuyu Xu
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  2. Xiaoyun Ji
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  3. Zheng Shi
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  4. Xin Chen
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Correspondence to Rui Tan or Hezhong Jiang.

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Xu, S., Ji, X., Shi, Z. et al. Chemical Composition of Alpinia oxyphylla Miq. and Chrysin Protective Activity on Neuron Cells. Pharm Chem J 56, 1477–1482 (2023). https://doi.org/10.1007/s11094-023-02817-0

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  • DOI: https://doi.org/10.1007/s11094-023-02817-0

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