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Cold Atmospheric Plasma as a Therapeutic Tool in Medicine and Dentistry

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Abstract

This comprehensive review explores decade-long research conducted on the applications of Cold Atmospheric Plasma (CAP) and Plasma Activated Liquids (PAL), including Plasma Activated Water (PAW), in the fields of Medicine and Dentistry. CAPs, operating at atmospheric pressure, offer unique advantages over conventional medical devices, generating Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) that interact with substances, enabling diverse applications. The review examined CAP and PAL efficacy against infectious diseases using in vitro, ex vivo, in vivo, and direct application methods. Significant strides were observed in wound healing, cancer treatment, and dental care. However, ensuring patient safety through rigorous plasma source standards remains crucial. The study underscores CAPs and PALs’ potential to transform medical and dental therapies, urging further research and development in these groundbreaking technologies. These findings highlight the transformative impact of CAPs and PALs, offering promising avenues for innovative medical and dental treatments.

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Funding

The authors acknowledge financial support from The São Paulo State Research Foundation (FAPESP, grants 2016/07196-6 and 2019/05856-7; fellowships 21/14181-3, 21/00046 − 7, 20/09481-5, and 23/02268-2) and Brazilian National Council for Scientific and Technological Development (309762/2021-9).

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Authors and Affiliations

  1. Department of Environment Engineering, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, Brazil

    Cristiane Yumi Koga-Ito, F. S. Miranda & N. V.M. Milhan

  2. Department of Physics, Guaratinguetá Faculty of Engineering, São Paulo State University (UNESP), Guaratinguetá, Brazil

    K. G. Kostov & F. Nascimento

  3. Plasmas and Processes Laboratory (LPP), Aeronautics Institute of Technology (ITA), São José dos Campos, Brazil

    N. F. Azevedo Neto & R. S. Pessoa

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  1. Cristiane Yumi Koga-Ito
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  4. N. V.M. Milhan
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  5. N. F. Azevedo Neto
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Contributions

CKI, RSP, KK, NM, FM, NFAN, and FN wrote the main manuscript text and prepared the Figures. All authors reviewed the manuscript.

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Correspondence to Cristiane Yumi Koga-Ito.

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Koga-Ito, C.Y., Kostov, K.G., Miranda, F.S. et al. Cold Atmospheric Plasma as a Therapeutic Tool in Medicine and Dentistry. Plasma Chem Plasma Process (2023). https://doi.org/10.1007/s11090-023-10380-5

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