Abstract
The emergence and spread of antimicrobial resistance have led to a dire need for innovative, alternative intervention strategies for infectious diseases, such as cold plasma technology. Plasma, known as the “fourth state of matter,” is a reactive mix of excited and fragmented gas molecules, ions, free electrons and radicals. Cold plasma is generated by a strong electric field ionising a gas and can be applied safely onto human tissue. Early studies at the turn of the century showed cold plasma has antimicrobial activity towards several types of bacteria and fungi, ushering in plasma medicine as a potential strategy to prevent and treat infections without using antimicrobial drugs. As a result, medical plasma devices have been developed for first applications in wound care and dentistry. However, these plasma devices have only passed through small, randomised controlled trials in diabetic foot ulcers and chronic leg ulcers, while dental applications of plasma devices are limited to in vitro and ex vivo experiments. These early studies showed promising results, thereby opening new avenues of plasma technology for medical therapies. This book chapter summarises the current state of knowledge concerning how plasma medicine could revolutionise biofilm infection control.
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Acknowledgements
Work in the laboratory and for this review was supported by the National Health and Medical Research Council (GNT1163634, GNT2004036), the University of Adelaide and The Hospital Research Foundation, Australia. The authors kindly acknowledge Animate Your Science (www.animateyour.science) for professional graphics.
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Abdo, A.I., Schmitt-John, T., Richter, K. (2022). Cold Plasma Therapy as a Physical Antibiofilm Approach. In: Richter, K., Kragh, K.N. (eds) Antibiofilm Strategies. Springer Series on Biofilms, vol 11. Springer, Cham. https://doi.org/10.1007/978-3-031-10992-8_10
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