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Sonic Hedgehog Signaling Pathway: A Role in Pain Processing

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Abstract

Pain, as one of the most prevalent clinical symptoms, is a complex physiological and psychological activity. Long-term severe pain can become unbearable to the body. However, existing treatments do not provide satisfactory results. Therefore, new mechanisms and therapeutic targets need to be urgently explored for pain management. The Sonic hedgehog (Shh) signaling pathway is crucial in embryonic development, cell differentiation and proliferation, and nervous system regulation. Here, we review the recent studies on the Shh signaling pathway and its action in multiple pain-related diseases. The Shh signaling pathway is dysregulated under various pain conditions, such as pancreatic cancer pain, bone cancer pain, chronic post-thoracotomy pain, pain caused by degenerative lumbar disc disease, and toothache. Further studies on the Shh signaling pathway may provide new therapeutic options for pain patients.

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This work was supported by National Natural Scientific Foundation of China (No. 81973890); and CACMS Innovation Fund (No. CI2021A01817).

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Authors and Affiliations

  1. Department of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beixiange 5, Xicheng District, Beijing, 100053, China

    Guangda Zheng & Yanju Bao

  2. Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, Liaoning Province, China

    Juanxia Ren & Lu Shang

Authors
  1. Guangda Zheng
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  2. Juanxia Ren
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  3. Lu Shang
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  4. Yanju Bao
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Contributions

GZ: conceptualization, writing—original draft. JR: writing—original draft. LS: writing—original draft. YB: conceptualization, writing—review and editing, supervision. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Yanju Bao.

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Zheng, G., Ren, J., Shang, L. et al. Sonic Hedgehog Signaling Pathway: A Role in Pain Processing. Neurochem Res 48, 1611–1630 (2023). https://doi.org/10.1007/s11064-023-03864-5

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  • DOI: https://doi.org/10.1007/s11064-023-03864-5

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