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Hedgehog signalling in vascular development

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Abstract

The Hedgehog family of proteins are powerful morphogens mediating embryonic development as well as adult morphogenesis and carcinogenesis. For example, excess hedgehog activity has been implicated in basal cell carcinoma, medulloblastoma and rhabdomyosarcoma. More recently, hedgehog signalling has been implicated in angiogenesis. While hedgehog signalling in adult angiogenesis may constitute a simple recapitulation of that in embryonic development, it should be appreciated that Hedgehog signalling occurs in embryonic angiogenesis in different developmental contexts. This article reviews the role of Hedgehog signalling in both embryonic and postnatal vascular development. The temporal importance of a window of hedgehog dependent angiogenesis during development is emphasised and illustrated using a whole mouse embryo culture system.

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Authors and Affiliations

  1. Clinical Research Centre, National Hospital Organisation Murayama Medical Centre, Musashimurayam-shi, Tokyo, 208–0011, Japan

    Takashi Nagase & Masafumi Machida

  2. Department of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Miki Nagase & Toshiro Fujita

Authors
  1. Takashi Nagase
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  2. Miki Nagase
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  3. Masafumi Machida
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  4. Toshiro Fujita
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Correspondence to Toshiro Fujita.

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Nagase, T., Nagase, M., Machida, M. et al. Hedgehog signalling in vascular development. Angiogenesis 11, 71–77 (2008). https://doi.org/10.1007/s10456-008-9105-5

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