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Diagnostic and therapeutic value of EVs in lungs diseases and inflammation

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Abstract

Extracellular vesicles (EVs) are membrane-derived messengers which have been playing an important role in the inflammation and pathogenesis of lung diseases. EVs contain varieties of DNA, RNA, and membrane receptors through which they work as a delivery system for bioactive molecules as well as intracellular communicators. EV signaling mediates tumor progression and metastasis. EVs are linked with many diseases and perform a diagnostic role in lung injury and inflammation so are used to diagnose the severity of diseases. EVs containing a variety of biomolecules communicate with the recipient cells during pathophysiological mechanisms thereby acquiring the attention of clinicians toward the diagnostic and therapeutic potential of EVs in different lung diseases. In this review, we summarize the role of EVs in inflammation with an emphasis on their potential as a novel candidate in the diagnostics and therapeutics of chronic obstructive pulmonary disease, asthma, and sarcoidosis.

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Acknowledgements

The authors are thankful to the Vice-chancellors of the University of Narowal, Narowal, Pakistan, the University of the Punjab, Lahore, Pakistan, and the University of Okara, Punjab, Pakistan, for providing support for the accomplishment of this study.

Funding

This study received no external funding.

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Author notes

  1. Ali Afzal, Muhammad Babar Khawar, Ume Habiba, Hanan Afzal, and Syeda Eisha Hamid have contributed equally to this work.

Authors and Affiliations

  1. Molecular Medicine and Cancer Therapeutics Lab, Department of Zoology, Faculty of Sciences, University of Central Punjab, Lahore, Pakistan

    Ali Afzal, Hanan Afzal & Syeda Eisha Hamid

  2. Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, China

    Ali Afzal & Muhammad Babar Khawar

  3. Applied Molecular Biology and Biomedicine Lab, Department of Zoology, University of Narowal, Narowal, Pakistan

    Muhammad Babar Khawar, Rimsha Abaidullah & Zoya Asif

  4. Department of Zoology, University of Education, Lahore, Pakistan

    Ume Habiba

  5. Cell & Molecular Biology Lab, Institute of Zoology, University of the Punjab, Lahore, Pakistan

    Mussarat Rafiq & Nadeem Sheikh

  6. Department of Zoology, University of Okara, Okara, Punjab, Pakistan

    Muddasir Hassan Abbasi

  7. Department of Biology, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan

    Tahaa Saeed

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  1. Ali Afzal
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Correspondence to Muhammad Babar Khawar.

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Afzal, A., Khawar, M.B., Habiba, U. et al. Diagnostic and therapeutic value of EVs in lungs diseases and inflammation. Mol Biol Rep 51, 26 (2024). https://doi.org/10.1007/s11033-023-09045-5

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